Preoperatively staging liver fibrosis using noninvasive method in Hepatitis B virus-infected hepatocellular carcinoma patients

Autor: Jia-Yin Yang, Feng Zhu, Li Jiang, Chang Liu, Hengyi Gao, Hang Zhang, Guang-Qin Xiao, Lunan Yan, Min Wang, Dawei Ye, Renyi Qin
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Liver Cirrhosis
Male
Cirrhosis
medicine.medical_treatment
medicine.disease_cause
Gastroenterology
preoperatively
0302 clinical medicine
Prospective Studies
Prospective cohort study
liver fibrosis
Univariate analysis
medicine.diagnostic_test
Liver Neoplasms
hepatocellular carcinoma
Middle Aged
Oncology
030220 oncology & carcinogenesis
Hepatocellular carcinoma
Area Under Curve
Preoperative Period
Regression Analysis
030211 gastroenterology & hepatology
Female
Prothrombin
Liver cancer
Research Paper
Adult
medicine.medical_specialty
Carcinoma
Hepatocellular
03 medical and health sciences
Hepatitis B
Chronic
Internal medicine
noninvasive
medicine
Hepatectomy
Humans
Neoplasm Staging
Retrospective Studies
Prothrombin time
Hepatitis B virus
business.industry
Platelet Count
Fibrinogen
Bilirubin
medicine.disease
Surgery
business
hepatitis B virus
Biomarkers
Zdroj: Oncotarget
ISSN: 1949-2553
Popis: // Hengyi Gao 1,2,4 , Feng Zhu 2 , Min Wang 2 , Hang Zhang 2 , Dawei Ye 3 , Jiayin Yang 4 , Li Jiang 5 , Chang Liu 5 , Renyi Qin 2 , Lunan Yan 4 and Guangqin Xiao 2,4 1 Department of General Surgery, Guizhou Provincial People’s Hospital, Guiyang, China 2 Department of Hepato-Pancreato-Biliary Surgery, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China 3 Department of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China 4 Department of Liver Surgery, West China Hospital of Sichuan University, Chengdu, China 5 Department of State Key Laboratory of Biotherapy and Pathology, West China Hospital of Sichuan University, Chengdu, China Correspondence to: Guangqin Xiao, email: // Keywords : hepatocellular carcinoma, liver fibrosis, hepatitis B virus, preoperatively, noninvasive Received : June 03, 2016 Accepted : December 05, 2016 Published : December 19, 2016 Abstract Background: Advanced liver fibrosis can result in serious complications (even patient’s death) after partial hepatectomy. Preoperatively percutaneous liver biopsy is an invasive and expensive method to assess liver fibrosis. We aim to establish a noninvasive model, on the basis of preoperative biomarkers, to predict liver fibrosis in hepatocellular carcinoma (HCC) patients with hepatitis B virus (HBV) infection. Methods: The HBV-infected liver cancer patients who had received hepatectomy were retrospectively and prospectively enrolled in this study. Univariate analysis was used to compare the variables of the patients with mild to moderate liver fibrosis and with severe liver fibrosis. The significant factors were selected into binary logistic regression analysis. Factors determined to be significant were used to establish a noninvasive model. Then the diagnostic accuracy of this novel model was examined based on sensitivity, specificity and area under the receiver-operating characteristic curve (AUC). Results: This study included 2,176 HBV-infected HCC patients who had undergone partial hepatectomy (1,682 retrospective subjects and 494 prospective subjects). Regression analysis indicated that total bilirubin and prothrombin time had positive correlation with liver fibrosis. It also demonstrated that blood platelet count and fibrinogen had negative correlation with liver fibrosis. The AUC values of the model based on these four factors for predicting significant fibrosis, advanced fibrosis and cirrhosis were 0.79-0.83, 0.83-0.85 and 0.85-0.88, respectively. Conclusion: The results showed that this novel preoperative model was an excellent noninvasive method for assessing liver fibrosis in HBV-infected HCC patients.
Databáze: OpenAIRE
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