Stem cell transplantation for mantle cell lymphoma: should it ever be used outside clinical trials?
| Autor: | Sweetenham Jw |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Male
Pathology medicine.medical_specialty Lymphoma Mantle-Cell Transplantation Autologous Disease-Free Survival Actuarial Analysis immune system diseases hemic and lymphatic diseases Antineoplastic Combined Chemotherapy Protocols medicine Humans Transplantation Homologous Prospective Studies Registries Aged Randomized Controlled Trials as Topic Salvage Therapy Clinical Trials as Topic Transplantation Hematopoietic cell business.industry Bone Marrow Purging Remission Induction Hematopoietic Stem Cell Transplantation Hematology Middle Aged Prognosis medicine.disease Combined Modality Therapy Survival Analysis Survival Rate Clinical trial Treatment Outcome surgical procedures operative medicine.anatomical_structure Female Mantle cell lymphoma Bone marrow Stem cell business Follow-Up Studies |
| Zdroj: | Bone Marrow Transplantation. 28:813-820 |
| ISSN: | 1476-5365 0268-3369 |
| DOI: | 10.1038/sj.bmt.1703255 |
| Popis: | The outlook for patients with mantle cell lymphoma is poor. The reported median survival in most published series is only 3 to 4 years, and even the most favorable prognostic groups have median survival rates of only 5 years, with no evidence of cure. The use of autologous and allogeneic stem cell transplantation in this disease has increased dramatically in recent years. Despite encouraging reports from single centers and registries, the impact of stem cell transplantation on the outcome for mantle cell lymphoma is unclear. Optimal first-line regimens for mantle cell lymphoma have yet to be defined, and it is therefore difficult to place the role of first remission transplantation in an appropriate context. Prospective randomized trials have been difficult to design and conduct in the absence of a well-defined 'standard' treatment. The role of stem cell transplantation as a salvage strategy is also unknown, although available data suggest that it does not improve survival in heavily pre-treated patients. In the absence of clear evidence for a survival advantage for patients receiving stem cell transplants for mantle cell lymphoma, entry into clinical trials should be a priority. |
| Databáze: | OpenAIRE |
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