Hypoglycemic Effect of the Rhizomes ofPolygala senegain Normal and Diabetic Mice and its Main Component, the Triterpenoid Glycoside Senegin-II
| Autor: | Yumi Nishiyama, Masataka Moriyasu, Mami Kako, Atsushi Kato, Momoyo Ichimaru, Toshihiro Miura |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Epinephrine medicine.medical_treatment Pharmaceutical Science Mice Inbred Strains Pharmacognosy Analytical Chemistry Mice Reference Values Diabetes mellitus Internal medicine Polygala senega Drug Discovery medicine Animals Hypoglycemic Agents Pharmacology chemistry.chemical_classification Plants Medicinal biology Plant Extracts Insulin Organic Chemistry Glycoside Metabolism medicine.disease biology.organism_classification Liver Glycogen Rhizome Endocrinology Diabetes Mellitus Type 2 Liver Complementary and alternative medicine chemistry Hyperglycemia Molecular Medicine Polygalaceae |
| Zdroj: | Planta Medica. 62:440-443 |
| ISSN: | 1439-0221 0032-0943 |
| Popis: | The hypoglycemic effect of the rhizomes of Polygala senega L. var. latifolia Torrey et Gray (Polygalaceae) was investigated in normal and KK-Ay mice, one of the model animals of non-insulin dependent diabetes mellitus (NIDDM). The n-butanol extract of senega rhizomes (SN) (5 mg/kg) reduced the blood glucose of normal mice from 191 +/- 3 to 120 +/- 3 mg/dl 4 hours after intraperitoneal administration (P < 0.001), and also showed a significant decrease in the glucose level of KK-Ay mice from 469 +/- 38 to 244 +/- 14 mg/dl under similar conditions (P < 0.001). But streptozotocin-induced diabetic mice did not experience a change in the blood glucose after administration of SN. We propose that the hypoglycemic effect of SN occurs without altering the insulin concentration. Moreover, SN needs the presence of insulin in order to act. In addition, one of the active components of the hypoglycemic effect was identified as a triterpenoid glycoside, senegin-II. |
| Databáze: | OpenAIRE |
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