Association between soil heavy metals and fatty liver disease in men in Taiwan: a cross sectional study

Autor: Wei-Wen Su, Iebin Lian, Maw Soan Soon, Chew Teng Kor, Pei Yuan Su, Wan Tzu Chang, Yen Chih Lin, Chia Chu Chang, Yu Fen Liang
Rok vydání: 2017
Předmět:
Zdroj: BMJ Open
ISSN: 2044-6055
DOI: 10.1136/bmjopen-2016-014215
Popis: Objectives Metabolic factors are major risk factors for non-alcoholic fatty liver disease although other factors may also contribute to development of fatty liver disease. We explored the association between exposure to soil heavy metals and prevalence of fatty liver disease. Methods We retrospectively analysed data from patients diagnosed with fatty liver disease in 2014 at the Health Evaluation Centre of Chang-Hua Christian Hospital (n=1137). We used residency data provided in the records of the Health Evaluation Centre and data for soil metal concentrations from a nationwide survey conducted by the Environmental Protection Administration of Taiwan. We studied the correlations between the severity of fatty liver disease and concentrations of soil heavy metals (arsenic, mercury, cadmium, chromium, copper, nickel, lead and zinc). Results The prevalence of moderate to severe fatty liver disease in our study was 26.5%. Using univariate and multivariate analysis, we demonstrated that the presence of soil heavy metals was a significant risk factor for fatty liver disease in men (OR 1.83, 95% CI 1.161 to 2.899, p=0.009). With stratification by body mass index (BMI) and gender, lean men with a BMI
Databáze: OpenAIRE