Selective cholinergic depletion of pedunculopontine tegmental nucleus aggravates freezing of gait in parkinsonian rats
| Autor: | Qiang Wang, Jing-Yu Chang, Peng Wen, Nanxiang Li, Ming Zhou, Hu Xiao, Min Li, Junbin Cai, Zhengyuan Xie, Wangming Zhang |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male Parkinson's disease Dopamine Motor Disorders Rotarod performance test Choline O-Acetyltransferase Lesion 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Pedunculopontine Tegmental Nucleus Medicine Animals Cholinergic neuron Oxidopamine Gait Pars Compacta business.industry Pars compacta General Neuroscience Immunotoxins Parkinson Disease medicine.disease Acetylcholine Cholinergic Neurons Rats 030104 developmental biology chemistry Rotarod Performance Test Cholinergic medicine.symptom business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Neuroscience letters. 659 |
| ISSN: | 1872-7972 |
| Popis: | Many patients of advanced Parkinson's disease (PD) suffer from intractable axial symptoms (severe gait and postural impairments), which were recently speculated to be more relevant to cholinergic degeneration in the brainstem than dopaminergic degeneration in the substantia nigra compacta (SNc). To investigate the role of the cholinergic cells of the pedunculopontine tegmental nucleus (PPTg) on motor deficits, especially the axial motor impairments, we measured and analyzed the gait performance of sham lesion rats, SNc dopaminergic lesion rats, PPTg cholinergic lesion rats, and combined lesion rats by using the CatWalk system. Motor performance of PPTg cholinergic lesion rats was also tested on the rotarod. Independent loss of cholinergic neurons in the PPTg did not induce gait disturbance in CatWalk, but PPTg lesion rats showed motor impairments on the rotarod when the demands of the motor task increased. Both SNc lesion rats and combined lesion rats displayed significant changes in many gait parameters, but the terminal dual stance increased much higher in combined lesion group than SNc lesion group. Furthermore, combined lesion rats showed more severe freezing of gait (FOG) than SNc lesion rats during behavioral re-evaluations after lesion. These results suggest that the PPTg cholinergic neurons play a vital role in the occurrence of FOG in PD. |
| Databáze: | OpenAIRE |
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