Antitumor, antioxidant and antimicrobial activities of Bersama engleriana (Melianthaceae)
| Autor: | Augustin Ephraim Nkengfack, Armelle T. Mbaveng, François-Xavier Etoa, Véronique Penlap Beng, J.J. Marion Meyer, Maurice Tsaffack, Victor Kuete, Namrita Lall |
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| Rok vydání: | 2008 |
| Předmět: |
Antioxidant
Free Radicals DPPH medicine.medical_treatment Microbial Sensitivity Tests Pharmacognosy Gram-Positive Bacteria Antioxidants Mycobacterium chemistry.chemical_compound Anti-Infective Agents Gram-Negative Bacteria Drug Discovery Botany Anthraquinones Toxicity Tests Acute medicine Animals Cameroon Phenols Rats Wistar Candida Pharmacology Traditional medicine Plant Extracts Antimicrobial Antineoplastic Agents Phytogenic Acute toxicity Rats chemistry Phytochemical Drug Screening Assays Antitumor |
| Zdroj: | Journal of Ethnopharmacology. 115:494-501 |
| ISSN: | 0378-8741 |
| Popis: | The aim of this study was to evaluate the antitumor, antioxidant and antimicrobial activities as well as the phytochemical composition and the acute toxicity of the methanolic extracts from the roots (BER), stem bark (BEB), leaves (BEL) and wood (BEW) of Bersama engleriana. The crown gall tumor and DPPH radical scavenging assays were used to detect respectively the antitumoral and oxidant activities. Agar diffusion and liquid dilution were used for antimicrobial tests and the phytochemical assays were conducted according to Harbone methods. The single-dose oral toxicity test was performed in accordance with the OPPTS 870.1100 and OECD 401guidelines. The phytochemical tests indicated the presence of flavonoids, phenols, triterpenes and anthraquinones in all extracts. Pronounced tumor reducing activity was observed with the extracts from the roots (69.32%) and leaves (65.42%). The DPPH scavenging activity showed that the extract from the leaves was the most active with 93.71% inhibition rate at the 1000 μg/ml. The results of antimicrobial activity showed that all tested extracts were active against all tested microbial species, including Gram-positive, and negative bacteria, the two Candida species and mycobacteria. The MIC values obtained ranged from 9.76 to 156.25 μg/ml. Under the conditions of the studied toxicity, all extracts were found to be non-toxic. The overall results of this study indicates that the extracts from the roots, stem bark, leaves and wood have interesting antioxidant properties and represent a potential source of medicine for the treatment of infectious diseases and cancer. |
| Databáze: | OpenAIRE |
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