Sunflower seed oil-enriched product can inhibit Ehrlich solid tumor growth in mice
| Autor: | Paulo Sousa, Flávia R.F. Nascimento, Márcia C.G. Maciel, Ana Paula S. Azevedo, Lucilene A. Silva, Mayara T. Pinheiro, Susanne C.P. Ferreira, Rosane N. M. Guerra, Kátia A.F. Nascimento |
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| Rok vydání: | 2004 |
| Předmět: |
Ratón
Linoleic acid Injections Subcutaneous Absorption (skin) Biology chemistry.chemical_compound Mice Drug Discovery Ascites medicine Animals Plant Oils Sunflower Oil Pharmacology (medical) Carcinoma Ehrlich Tumor Lymph node Pharmacology General Medicine Molecular biology Infectious Diseases Lymphatic system medicine.anatomical_structure Oncology chemistry Biochemistry Sunflower seed Lymph medicine.symptom |
| Zdroj: | Chemotherapy. 52(2) |
| ISSN: | 0009-3157 |
| Popis: | Background: Sunflower seed oil (SSO) effect on solid and ascitic forms of Ehrlich tumor was evaluated. Methods: Solid or ascitic Ehrlich tumor-bearing Swiss mice were treated daily, by subcutaneous route, with 200 µl of SSO. The solid tumor-bearing footpad was measured every 3 days and ascitic tumor-bearing mice had their ascites collected and quantified. At the end of the SSO treatment, the total cell number in lymphoid organs was quantified. Results: Subcutaneous treatment with SSO inhibits the solid tumor growth and increases lymph node cell number in animals with solid tumor, but has no effect on animals with ascitic tumor. Conclusions: SSO can delay the solid tumor growth, possibly due to better absorption of this treatment by draining lymph nodes. |
| Databáze: | OpenAIRE |
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