Nano-composites chitosan-curcumin synergistically inhibits the oxidative stress induced by toxic metal cadmium
| Autor: | Gasem M. Abu Taweel, Mohammad Kaleem Ahmad, Syed Hidayathulla |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
inorganic chemicals
0301 basic medicine Curcumin Erythrocytes Magnetic Resonance Spectroscopy Antioxidant medicine.medical_treatment chemistry.chemical_element Pharmacology Kidney medicine.disease_cause Biochemistry Nanocomposites Superoxide dismutase Mice 03 medical and health sciences chemistry.chemical_compound 0404 agricultural biotechnology Structural Biology Spectroscopy Fourier Transform Infrared mental disorders medicine TBARS Animals Molecular Biology health care economics and organizations Chitosan Cadmium biology Superoxide Dismutase technology industry and agriculture 04 agricultural and veterinary sciences General Medicine Glutathione respiratory system 040401 food science Oxidative Stress 030104 developmental biology Liver chemistry Catalase biology.protein Oxidative stress |
| Zdroj: | International Journal of Biological Macromolecules. 108:591-597 |
| ISSN: | 0141-8130 |
| Popis: | The present study intends to compare the influence of pre-treatment with nanoparticles of curcumin (Cr-NPS), chitosan (Ch-NPS) and nanocomposites chitosan-curcumin (CC-NPS) on cadmium (Cd)-induced oxidative damage in the liver, kidneys, and blood indices in Swiss strain adult male mice. The pretreated mice with Cr-NPS, Ch-NPS, and CC-NPS were exposed to Cd (10mg/kg) for three weeks. The non-enzymatic Oxidative Stress (OS) indices like lipid peroxides (TBARS), reduced total glutathione (GSH), enzymatic OS indices like catalase (CAT), glutathione S-transferase (GST) and superoxide dismutase (SOD) were estimated together with some blood indices. Cadmium was able to induce a significant increase in TBARS and a significant decrease in GSH, GST, CAT and SOD levels in all the tissues, which were pretreated with nanocomposite. Furthermore, the blood indices like counts of red and white blood cells, platelets, hemoglobin and packed cell volume were also depleted due to Cd exposure but remained unaffected and kept under normal levels in pretreated mice group. The results indicate that Cr-NPS, Ch-NPS, and CC-NPS may act as natural antioxidants and when compared among the three, CC-NPS appears to be the best antioxidant. |
| Databáze: | OpenAIRE |
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