The comparative efficacy of carbamazepine low and high serum level and lithium carbonate in the prophylaxis of affective disorders
| Autor: | Kenneth Thau, Ch. Simhandl, E. Denk |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Adult
Male Bipolar Disorder Adolescent Lithium (medication) medicine.medical_treatment chemistry.chemical_compound Lithium Carbonate Recurrence medicine Humans Bipolar disorder Depression (differential diagnoses) Aged Psychiatric Status Rating Scales Depressive Disorder Chemotherapy Dose-Response Relationship Drug High serum Lithium carbonate Carbamazepine Middle Aged medicine.disease Long-Term Care Psychiatry and Mental health Clinical Psychology Anticonvulsant chemistry Delayed-Action Preparations Anesthesia Female Psychology Follow-Up Studies medicine.drug |
| Zdroj: | Journal of Affective Disorders. 28:221-231 |
| ISSN: | 0165-0327 |
| DOI: | 10.1016/0165-0327(93)90057-q |
| Popis: | Summary The prophylactic efficacy of carbamazepine slow release (CBZ) at ke different blood levels and lithium carbonate slow release (LI) was compared in a retrospective/prospective, randomized, 2-year open trial. 84 patients with a DSM-III-R diagnosis of recurrent affective disorder who had no prophylactic medication in the 2 years preceding the trial (no LI nonresponders), were randomly allocated to three treatment groups: CBZ low (l-25 pmol/l), CBZ high (28-40 pmol/l) and LI (0.6-0.8 pmol/l). Fifty-eight patients completed the full observation period of 2 years, 26 patients dropped out. There were no statistically significant differences in the efficacy of the prophylactic treatment for bipolar patients. For the unipolar patients, the group with a low CBZ serum level showed no reduction in the duration of episodes. The two other treatment groups seem to be equal in attenuation of a unipolar course of an affective disorder. |
| Databáze: | OpenAIRE |
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