Association of Arterial Spin Labeling Parameters With Cognitive Decline, Vascular Events, and Mortality in a Memory-Clinic Sample
Autor: | Bibek, Gyanwali, Henk Jmm, Mutsaerts, Chuen Seng, Tan, Omar Rajab, Kaweilh, Jan, Petr, Christopher, Chen, Saima, Hilal |
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Přispěvatelé: | Radiology and nuclear medicine |
Jazyk: | angličtina |
Rok vydání: | 2022 |
Předmět: | |
Zdroj: | Gyanwali, B, Mutsaerts, H J MM, Tan, C S, Kaweilh, O R, Petr, J, Chen, C & Hilal, S 2022, ' Association of Arterial Spin Labeling Parameters With Cognitive Decline, Vascular Events, and Mortality in a Memory-Clinic Sample ', American Journal of Geriatric Psychiatry, vol. 30, no. 12, pp. 1298-1309 . https://doi.org/10.1016/j.jagp.2022.06.007 American Journal of Geriatric Psychiatry 30(2022)12, 1298-1309 American Journal of Geriatric Psychiatry, 30(12), 1298-1309. Lippincott Williams and Wilkins |
ISSN: | 1064-7481 |
DOI: | 10.1016/j.jagp.2022.06.007 |
Popis: | Background: Cognitive decline in older adults has been attributed to reduced cerebral blood flow (CBF). Recently, the spatial coefficient of variation (sCoV) of ASL has been proposed as a proxy marker of cerebrovascular insufficiency. We investigated the association between baseline ASL parameters with cognitive decline, incident cerebrovascular disease and risk of vascular events and mortality. Design, Setting and Participants: 368 memory-clinic patients underwent three-annual neuropsychological assessments and brain MRI scans at baseline and follow-up. MRIs were graded for white matter hyperintensities (WMH), lacunes, cerebral microbleeds (CMBs), cortical infarcts and intracranial stenosis. Baseline gray (GM) and white matter (WM) CBF and GM-sCoV were obtained with ExploreASL from 2D-EPI pseudo-continuous ASL images. Cognitive assessment was done using a validated neuropsychological battery. Data on incident vascular events (heart disease, stroke, transient ischemic attack) and mortality were obtained. Results: Higher baseline GM-sCoV was associated with decline in the memory domain over three years of follow-up. Furthermore, higher GM-sCoV was associated with a decline in the memory domain only in participants without dementia. Higher baseline GM-sCoV was associated with progression of WMH and incident CMBs. During a mean follow-up of 3 years, 29 (7.8%) participants developed vascular events and 18 (4.8%) died. Participants with higher baseline mean GM-sCoV were at increased risk of vascular events. Conclusions: Higher baseline GM-sCoV of ASL was associated with a decline in memory and risk of incident cerebrovascular disease and vascular events, suggesting that cerebrovascular insufficiency may contribute to accelerated cognitive decline and worse clinical outcomes in memory clinic participants. |
Databáze: | OpenAIRE |
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