Effects of Balneotherapy in Jeju Magma-Seawater on Knee Osteoarthritis Model
Autor: | Youn-Ho Lee, Jina Oh, Young-Joon Lee, Sae-Kwang Ku, Phil Hyun Song, Choong-Gon Kim, Dae-Geon Lee, Chang-Hyun Song |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
Balneotherapy
Male Bone density Bathing Compressive Strength Knee Joint medicine.medical_treatment Anterior cruciate ligament lcsh:Medicine Apoptosis Osteoarthritis Article Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine Bone Density medicine Animals Seawater RNA Messenger lcsh:Science Saline Cell Proliferation 030203 arthritis & rheumatology Bone mineral Inflammation Multidisciplinary business.industry Balneology lcsh:R Diclofenac Sodium Osteoarthritis Knee medicine.disease Matrix Metalloproteinases Disease Models Animal medicine.anatomical_structure Cartilage Preclinical research 030220 oncology & carcinogenesis Anesthesia Proteolysis lcsh:Q Inflammation Mediators business |
Zdroj: | Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020) Scientific Reports |
ISSN: | 2045-2322 |
Popis: | Balneotherapy is a common non-pharmacological treatment for osteoarthritis (OA), however, the efficacy is controversial in knee OA. Jeju magma-seawater (JMS) has high contents of various minerals, which has anti-inflammatory and antioxidant properties via an oral route. Thus, we examined the effects of JMS bathing on knee OA and the combination effects with diclofenac sodium as an anti-inflammatory drug. Knee OA was induced by transection of the anterior cruciate ligament and the partial meniscectomy in rat. The rats were administered subcutaneously saline or diclofenac sodium in saline, followed by bathing in thermal distilled water or JMS for 8 weeks. The model represented the characteristic changes of the cartilage degradation, osteophyte formation and synovial inflammation, and the relevant symptoms of the joint swelling and stiffness. However, the JMS bathing reduced the joint thickness and improved the mobility. It also contributed to a well-preserved tissue supported by increases in bone mineral density of the joint and decreases in Mankin scores in the cartilages. The effects involved anti-inflammation, chondroprotection, anti-apoptosis, and chondrogenesis. Overall, the JMS bathing in combination with diclofenac sodium showed a similar trend associated with synergic effects. It suggests that JMS bathing can be promising for a clinical use in knee OA. |
Databáze: | OpenAIRE |
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