Macrophage polarization and function: new prospects for fibrotic disease
| Autor: | Wen Zhang, Yaqin Wang, Jian Zuo, Kui Yang, Hui Jiang, Lu Chen, Dexi Zhou, Zhenyu Xu, Jiajie Luan |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Immunology Macrophage polarization Inflammation Disease Biology Monocytes Pathogenesis 03 medical and health sciences 0302 clinical medicine Fibrosis medicine Animals Humans Immunology and Allergy Macrophage Cell Lineage Th1-Th2 Balance Macrophages Cell Differentiation Cell Biology medicine.disease 030104 developmental biology Liver 030220 oncology & carcinogenesis Cytokines medicine.symptom Wound healing |
| Zdroj: | Immunology & Cell Biology. 95:864-869 |
| ISSN: | 1440-1711 0818-9641 |
| DOI: | 10.1038/icb.2017.64 |
| Popis: | Fibrosis is commonly regarded as a pathological and dynamic process with the hallmarks of chronic inflammation and wound healing. Emerging evidence indicates that heterogeneous monocyte-macrophage lineage cells are indispensable for mounting either pro-fibrotic or anti-fibrotic responses in different stages during fibrotic pathogenesis. This review highlights the evolving roles of macrophage polarization and functions linked to fibrosis in multiple organs. In the future, identifying the molecular and cellular factors that influence the macrophage phenotypic balance may provide novel therapeutic approaches for fibrotic diseases. |
| Databáze: | OpenAIRE |
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