The Effect of Suppressive Therapy of Nontoxic Diffuse Goiter on Serum Levels of Thyroxine, 3,5,3‘-Triiodothyronine and 3,3’,5‘-Triiodothyronine
| Autor: | L. Skovsted, Jens P. Kampmann, Jens Mølholm Hansen, Klaus Johansen, H. Perrild |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty Time Factors Triiodothyronine Reverse Pituitary thyroid axis chemistry.chemical_compound Internal medicine Diffuse goiter Internal Medicine medicine Humans In patient Aged Triiodothyronine Goiter business.industry Middle Aged Reverse triiodothyronine Thyroxine Endocrinology chemistry Female business hormones hormone substitutes and hormone antagonists Nontoxic goiter |
| Zdroj: | Acta Medica Scandinavica. 205:25-30 |
| ISSN: | 0001-6101 |
| Popis: | We studied the effect of suppressive therapy with graded doses of thyroxine (T4) on serum levels of T4, 3,5,3′-triiodothyronine (T3) and 3,3′,5′-triiodothyronine (rT3) in patients with diffuse, nontoxic goiter. For comparison and in order to elucidate the degree of suppression of the pituitary thyroid axis by T3 the effect of suppressive therapy with T3 was studied in the same type of patients. We found that T4 in serum rose significantly to a constant level during T4 treatment (0.10, 0.15 and 0.20 mg/day). Dose-related rises in T4 were only seen after 3 months of treatment. T3 and rT3 only changed minimally. The T4/T3 ratio rose to a constant level during the initial 3 months of treatment. T3/rT3 ratio remained unchanged. No dose-related differences in T3/rT4 and T3/rT3 ratio were observed. Treatment with T3 in doses of 0.06 mg per day caused a significant but slow fall in T4 and rT3 to hypothyroid levels while T3 only rose slightly. The T4/T3 ratio dropped significantly during T3 therapy. |
| Databáze: | OpenAIRE |
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