Simultaneous Multiorgan Presence of Human Herpesvirus 8 and Restricted Lymphotropism of Epstein‐Barr Virus DNA Sequences in a Human Immunodeficiency Virus–Negative Immunodeficient Infant
| Autor: | María-José Lozano, Javier Gonzalo Ocejo-Vinyals, José Javier Gómez-Román, Francisco Leyva-Cobián, Pablo Sánchez-Velasco, Reyes Flores |
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| Rok vydání: | 2001 |
| Předmět: |
Epstein-Barr Virus Infections
Herpesvirus 4 Human Pathology medicine.medical_specialty Lymphoid Tissue Spleen Opportunistic Infections medicine.disease_cause Polymerase Chain Reaction Herpesviridae Virus HIV Seronegativity hemic and lymphatic diseases DiGeorge Syndrome medicine Humans Immunology and Allergy Gammaherpesvirinae Endothelium In Situ Hybridization biology Macrophages Infant Newborn virus diseases Epithelial Cells Herpesviridae Infections Sequence Analysis DNA biology.organism_classification medicine.disease Epstein–Barr virus Virology Blotting Southern Infectious Diseases medicine.anatomical_structure Lymphatic system DNA Viral Herpesvirus 8 Human Leukocytes Mononuclear Primary immunodeficiency Female Bone marrow |
| Zdroj: | The Journal of Infectious Diseases. 183:338-342 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1086/317925 |
| Popis: | Because a profound dysregulation of the immune system occurs in primary immunodeficiencies, viral infections are not uncommon. Human herpesvirus (HHV)-8 DNA was detected by polymerase chain reaction (PCR) analysis, Southern blotting, and in situ hybridization (ISH) in peripheral blood mononuclear cells and lymphoid organs (bone marrow, spleen, and lymph nodes) and endothelial and epithelial cells and macrophages from several organs (skin, lung, esophagus, intestine, choroid plexus [but not in brain or cerebellum], heart, striated muscle, liver, and kidney) of a human immunodeficiency virus-negative infant with DiGeorge anomaly who died of disseminated infection. Epstein-Barr virus DNA sequences were detected in the spleen and lymph nodes (by PCR and ISH) and in bone marrow (only by ISH) but not in blood or nonlymphoid organs. This report is believed to be the first of multiorgan dissemination of HHV-8 in a primary immunodeficiency. |
| Databáze: | OpenAIRE |
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