The effect of heavy metal ions on the rate of decomposition of N-ethyl-N-nitrosourea and other carcinogenic N-nitrosamides
| Autor: | Rudolf Preussmann, R Deutsch-Wenzel, G Eisenbrand |
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| Rok vydání: | 1975 |
| Předmět: |
inorganic chemicals
Cancer Research Methylnitronitrosoguanidine Nitrosourea Compound Metal ions in aqueous solution Inorganic chemistry Nitrosourea Compounds Chemical kinetics Blood serum Drug Stability Nitrosomethylurethane Nickel otorhinolaryngologic diseases Qualitative inorganic analysis Drug Interactions Edetic Acid Aqueous solution Chemistry Water General Medicine Hydrogen-Ion Concentration Decomposition Solutions Blood Oncology Ethylnitrosourea Copper Half-Life Nitroso Compounds |
| Zdroj: | Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology. 84(1) |
| ISSN: | 0084-5353 |
| Popis: | The decomposition of ethylnitrosourea (ENU) in aqueous solution is enhanced by Cu2+ ions. Ni2+ shows a similar, but less pronounced effect. The decomposition rate of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), a compound known to be relatively stable in aqueous solution, is strongly enhanced by the addition of Cu2+ and to a smaller extent also by Ni2+ ions. On the other hand the stability of N-methyl-N-nitrosourethane is not influenced by heavy meatal ions. The influence of Cu2+ ions on the decomposition rate of ENU is similar to that of OH-anions, influencing the reaction kinetics on a molar basis. The increase in decomposition rate of ENU by copper ions is not seen in the presence of blood serum or other complexing agents. The results are discussed in relation to the known enhancement in toxicity and carcinogenicity of ENU by heavy metal salts in animal experiments. |
| Databáze: | OpenAIRE |
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