Recognition of stapled histone H3K4me3 peptides by epigenetic reader proteins

Autor:	Peter Betlem, Marijn N. Maas, Jim Middelburg, Bas J. G. E. Pieters, Jasmin Mecinović
Rok vydání:	2022
Předmět:	Histones Materials Chemistry Metals and Alloys Ceramics and Composites General Chemistry Synthetic Organic Chemistry Peptides Methylation Catalysis Surfaces Coatings and Films Electronic Optical and Magnetic Materials Epigenesis Genetic
Zdroj:	Chemical Communications, 58, 87, pp. 12196-12199 Chemical Communications, 58, 12196-12199
ISSN:	1359-7345
DOI:	10.1039/d2cc04294k
Popis:	The flexible N-terminal histone tails are a subject of numerous posttranslational modifications, including methylation. We report development of stapled histone peptides bearing trimethyllysine as ligands for epigenetic reader proteins. Stronger or weaker binding affinities have been observed for stapled histone peptides relative to linear histones, indicating that selectivity towards reader proteins can be achieved.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39855802760f3e9ad515fb090a071d02 https://doi.org/10.1039/d2cc04294k Zobrazit plný text záznamu