SYNTHESES AND CARDIOVASCULAR ACTIVITY OF STEREOISOMERS AND DERIVATIVES OF EBURNANE ALKALOIDS

Autor:	Martin Kessel, Janos Kreidl, Maria Farkas, Pál Sohár, Zsolt Szombathelyi, Laszlo Czibula, Andras Nemes, Karpati Egon, Gyorgy Visky
Předmět:	chemistry.chemical_compound Chemistry Stereochemistry Alkaloid Organic Chemistry Biological activity Nuclear Overhauser effect Nuclear magnetic resonance spectroscopy Physical and Theoretical Chemistry DEPT Eburnamine
Zdroj:	ResearcherID
Popis:	The synthesis of all the possible isomers of the eburnameninevincamine type alkaloids 1b, 2a, 3a and derivatives 4, 8, 9, 10 is described. Structures were determined by 1H- and 13C-NMR spectroscopy including special techniques such as DR, DEPT, DNOE, and 2D-HSC. In contrast to the known cerebrovascular effects of cis-(3S,16S) compounds, trans-(3S,16R) derivatives show a significant peripheral vasodilator effect.
Databáze:	OpenAIRE
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