Paranuclear blue inclusions: An aid in the cytopathologic diagnosis of primary and metastatic pulmonary small-cell carcinoma
| Autor: | Philip S. Coogan, Sophie K. Thompson, M. Salah Shurbaji, Rejeana K. Mullins |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Pathology
medicine.medical_specialty Lung Neoplasms Histology Lymphoma Cytodiagnosis Papanicolaou stain Small-cell carcinoma Pathology and Forensic Medicine Metastasis Diagnosis Differential Carcinoma Non-Small-Cell Lung medicine Carcinoma Humans Carcinoma Small Cell neoplasms Retrospective Studies Inclusion Bodies Lung Staining and Labeling medicine.diagnostic_test business.industry Respiratory disease General Medicine medicine.disease humanities respiratory tract diseases Fine-needle aspiration medicine.anatomical_structure business |
| Zdroj: | Diagnostic Cytopathology. 10:332-335 |
| ISSN: | 1097-0339 8755-1039 |
| Popis: | Accurate diagnosis of small-cell carcinoma of the lung (SCLC) is clinically important because of the therapeutic implications. SCLC must be distinguished from non-small-cell carcinoma (NSCLC) and lymphoma. Paranuclear blue inclusions (PBIs) were recently described as a feature of metastatic SCLC on air-dried Wright-stained bone marrow aspirate smears. To determine the utility of PBIs in distinguishing SCLC from NSCLC and lymphoma, we evaluated air-dried Diff-Quik-stained smears from 103 fine-needle aspiration (FNA) specimens and 14 touch imprint specimens. PBIs were identified in 24 (89%) of 27 cases of SCLC, in 6 (9%) of 64 non-small-cell carcinomas (P < 0.00001), and in two (8%) of the 26 lymphoma cases (P < 0.00001). No PBIs were seen on any of the alcohol-fixed Papanicolaou or hematoxylin-eosin (H&E) stained smears examined. In conclusion, PBIs appear to be a feature of SCLC on air-dried cytologic material stained with Romanowsky type stains. In the presence of cytologic features of SCLC, the identification of PBIs provides a useful diagnostic feature for diferentiating between SCLC and NSCLC carcinomas, and between SCLC and lymphomas in FNA specimens and touch imprints from surgical specimens. © 1994 Wiley-Liss, Inc. |
| Databáze: | OpenAIRE |
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