Immune Status in the Acute Period of Severe Brain Injury in the Development of Pyoseptic Complications
| Autor: | T. I. Borshchikova, N. N. Epifantseva, G. S. Surzhikova, Yu. A., Churlyaev, S. A. Klochkova-Abelyants, L. G. Khering, A. V. Yekimovskikh |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
APACHE II biology RC86-88.9 medicine.drug_class business.industry Antibiotics Glasgow Coma Scale Medical emergencies. Critical care. Intensive care. First aid Disease Critical Care and Intensive Care Medicine medicine.disease Gastroenterology Immune system Immunoglobulin M Internal medicine Immunology medicine biology.protein Platelet business Immunodeficiency |
| Zdroj: | Obŝaâ Reanimatologiâ, Vol 6, Iss 3 (2010) |
| ISSN: | 2411-7110 1813-9779 |
| DOI: | 10.15360/1813-9779-2010-3-35 |
| Popis: | Objective: to study the time course of immunological changes in patients with acute severe brain injury (SBI) and their use along with the integrated indices of evaluation of its severity to define criteria for predicting the development of pyoseptic complications. Subjects and methods. Immunological parameters were studied in 53 SBI patients aged 17—65 years on days 1, 7, and 14 days after injury. There were 2 groups: 1) 16 patients without complications; 2) 37 patients with pyoseptic complications in the acute period of the disease. The integral scales SIRS, CPIS, Glasgow coma scale (GCS), APACHE II, laboratory parameters (immunograms, platelets, soluble fibrin-monomer complexes, and medium molecular weight peptides) in the prediction of pyoseptic complications were analyzed in patients with SBI. A control group consisted of 23 apparently healthy individuals. Results. The found immunological parameters lead to the conclusion that patients with SBI had significant immunodeficiency of mixed genesis by the cellular and humoral types in the acute period of the disease, immune system activation at week 2 of the disease in the development of pyoseptic complications. The decrease in the immunoregulatory index or less than 1.17 or its increase or more than 2.55 on day 1 after SBI was associated with the higher risk of pyoseptic complications. Some indices of an immunogram and the integral scales APACHE II, SIRS, CPIS, and GCS were found to be of low importance in the prediction of pyoseptic complications in SBI. Multivariate regression analysis showed that indices, such as the relative blood count of CD3+, CD95+ lymphocytes, platelets, the serum levels of immunoglobulin M and medium molecular weight peptides (at 262 nm), as well as GCS scores and the maximum temperature on the day of the investigation, were of the greatest value in the construction of prognostic models. Conclusion. The proposed models for the prediction of pyoseptic complications in the acute period of SBI may be useful in optimizing the use of antibiotics and immunomodulating therapy. Key words: severe brain injury, prediction of pyoseptic complications, cellular and humoral immunological parameters. |
| Databáze: | OpenAIRE |
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