Cardiovascular Diseases, Depression Disorders and Potential Effects of Omega-3 Fatty Acids
| Autor: | Andrej Dukát, Jana Muchová, Jana Trebatická, Zdeňka Ďuračková |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Physiology Disease 030204 cardiovascular system & hematology medicine.disease_cause Proinflammatory cytokine 03 medical and health sciences 0302 clinical medicine Internal medicine Fatty Acids Omega-3 medicine Humans Endothelial dysfunction Depression (differential diagnoses) Depressive Disorder business.industry General Medicine Metabolism medicine.disease Dietary Fats Pathophysiology Oxidative Stress Endocrinology Cardiovascular Diseases Inflammation Mediators Signal transduction business 030217 neurology & neurosurgery Oxidative stress Signal Transduction |
| Zdroj: | Physiological Research. :363-382 |
| ISSN: | 1802-9973 0862-8408 |
| DOI: | 10.33549/physiolres.933430 |
| Popis: | Cardiovascular disease (CVD) and depressive disorders (DD) are two of the most prevalent health problems in the world. Although CVD and depression have different origin, they share some common pathophysiological characteristics and risk factors, such as the increased production of proinflammatory cytokines, endothelial dysfunction, blood flow abnormalities, decreased glucose metabolism, elevated plasma homocysteine levels, oxidative stress and disorder in vitamin D metabolism. Current findings confirm the common underlying factors for both pathologies, which are related to dramatic dietary changes in the mid-19th century. By changing dietary ratio of omega-6 to omega-3 fatty acids from 1:1 to 15-20:1 some changes in metabolism were induced, such as increased pro-inflammatory mediators and modulations of different signaling pathways following pathophysiological response related to both, cardiovascular diseases and depressive disorders. |
| Databáze: | OpenAIRE |
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