Iridium(iii ) complexes with 1,10-phenanthroline-based N^N ligands as highly selective luminescent G-quadruplex probes and application for switch-on ribonuclease H detection
| Autor: | Tian-Shu Kang, Lihua Lu, Chung-Hang Leung, Chao Yang, Wanhe Wang, Dik-Lung Ma |
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| Rok vydání: | 2016 |
| Předmět: |
biology
Stereochemistry Phenanthroline Biomedical Engineering chemistry.chemical_element 02 engineering and technology General Chemistry General Medicine 010402 general chemistry 021001 nanoscience & nanotechnology G-quadruplex Highly selective 01 natural sciences RNase H activity 0104 chemical sciences chemistry.chemical_compound chemistry biology.protein Molecule General Materials Science Iridium 0210 nano-technology RNase H Luminescence |
| Zdroj: | Journal of Materials Chemistry B. 4:6791-6796 |
| ISSN: | 2050-7518 2050-750X |
| DOI: | 10.1039/c6tb02316a |
| Popis: | A systematic study was performed to investigate the relationship between molecular structure and G-quadruplex sensing ability for a series of structurally related cyclometallated iridium(iii) complexes. The novel complex 7 was used to construct a label-free luminescent switch-on G-quadruplex-based assay for RNase H activity in buffered solution. The constructed detection platform was simple, low-cost and highly sensitive for RNase H, and functioned effectively in the presence of cellular debris. |
| Databáze: | OpenAIRE |
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