RGTA® or ReGeneraTing Agents mimic heparan sulfate in regenerative medicine: from concept to curing patients
| Autor: | Pascal Desgranges, Fernando Siñeriz, Jean-Louis Saffar, Johan W. van Neck, Gilbert Zakine, Kim Lee Rice, Denis Barritault, Marie Gilbert-Sirieix, Dulce Papy-Garcia, Christophe Baudouin |
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| Přispěvatelé: | Plastic and Reconstructive Surgery and Hand Surgery |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Normal tissue Drug Evaluation Preclinical Review Biology Protective Agents Regenerative Medicine Regenerative medicine Biochemistry Bone and Bones Extracellular matrix Heparan sulfate mimics 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Biomimetic Materials Signaling proteins Regeneration Animals Humans Molecular Biology Tissue homeostasis Glycosaminoglycans Skin Clinical Trials as Topic Wound Healing Tissue Scaffolds Muscles Heparan sulfate Cell Biology Chronic injury Cell biology Extracellular Matrix RGTA® Gastrointestinal Tract 030104 developmental biology chemistry Extracellular scaffold 030221 ophthalmology & optometry Heparitin Sulfate Wound healing Corneal Injuries |
| Zdroj: | Glycoconjugate Journal Glycoconjugate Journal, 34(3), 325-338. Springer Netherlands |
| ISSN: | 1573-4986 0282-0080 |
| Popis: | The importance of extracellular matrix (ECM) integrity in maintaining normal tissue function is highlighted by numerous pathologies and situations of acute and chronic injury associated with dysregulation or destruction of ECM components. Heparan sulfate (HS) is a key component of the ECM, where it fulfils important functions associated with tissue homeostasis. Its degradation following tissue injury disrupts this delicate equilibrium and may impair the wound healing process. ReGeneraTing Agents (RGTA®s) are polysaccharides specifically designed to replace degraded HS in injured tissues. The unique properties of RGTA® (resistance to degradation, binding and protection of ECM structural and signaling proteins, like HS) permit the reconstruction of the ECM, restoring both structural and biochemical functions to this essential substrate, and facilitating the processes of tissue repair and regeneration. Here, we review 25 years of research surrounding this HS mimic, supporting the mode of action, pre-clinical studies and therapeutic efficacy of RGTA® in the clinic, and discuss the potential of RGTA® in new branches of regenerative medicine. |
| Databáze: | OpenAIRE |
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