Thiopental versus propofol on the outcome of the newborn after caesarean section: An impact study
Autor: | Joseph Bouyou, Fabien Espitalier, Francis Remerand, Marc Laffon, Olivier Montandrau |
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Rok vydání: | 2019 |
Předmět: |
Adult
Neonatal intensive care unit Placenta medicine.medical_treatment Impact study Anesthesia General Critical Care and Intensive Care Medicine Hospitals University Young Adult 03 medical and health sciences Fetus 0302 clinical medicine Pregnancy Anesthesia Obstetrical Humans Medicine General anaesthesia Caesarean section Prospective Studies 030212 general & internal medicine Rapid Sequence Induction and Intubation Thiopental Prospective cohort study Propofol Cesarean Section business.industry Infant Newborn Pregnancy Outcome 030208 emergency & critical care medicine General Medicine University hospital Anesthesiology and Pain Medicine Elective Surgical Procedures Anesthesia Apgar Score Female Apgar score France Emergencies business medicine.drug |
Zdroj: | Anaesthesia Critical Care & Pain Medicine. 38:631-635 |
ISSN: | 2352-5568 |
Popis: | Summary Background In 2011, the company that produced thiopental in France and in the United States stopped its marketing. Because of limited evidences, the choice of the best induction agent for caesarean section remains controversial, especially in emergency. The objective of this study was to compare the effects of propofol versus thiopental on the Apgar score of the newborn. Methods Newborns delivered by elective or emergency caesarean section under general anaesthesia in a university hospital were included from January 2009 to December 2013. Two periods, according to the hypnotic drug used, were compared in this before-and-after comparative study: thiopental before May 2011 and propofol after. The primary outcome was to compare the proportion of newborns with a 5-minute Apgar Score Results 367 newborns were enrolled, 178 in thiopental group and 189 in propofol group. Demographic and clinical characteristics were similar in both groups. The occurrence of a 5-minute Apgar Score less than 7 was not influenced by the use of propofol (OR 1.40 [CI 95% 0.90–2.20] P = 0.135). Blood gas analyses and admission's rate in neonatal intensive care unit were similar in both groups. Conclusions Thiopental and propofol do not appear to present significant difference in term of outcome of the newborn after caesarean section. In this situation, propofol may probably be a reliable alternative to the supply reduction of thiopental imposed by forces. Prospective studies are required to confirm the safety of propofol, particularly in the long term. |
Databáze: | OpenAIRE |
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