Social and cognitive functioning, urbanicity and risk for schizophrenia
| Autor: | Moti Shmushkevitz, Gad Lubin, Shlomo Noy, Jim van Os, Jonathan Rabinowitz, Mark Weiser, Michael H. Davidson, Efrat Kravitz, Abraham Reichenberg, Haim Y. Knobler, Daniella Nahon |
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| Rok vydání: | 2007 |
| Předmět: |
Male
Psychosis Adolescent Population Developmental psychology Cohort Studies 03 medical and health sciences 0302 clinical medicine medicine Humans Genetic Predisposition to Disease Registries 030212 general & internal medicine Cognitive skill Israel Risk factor education Population Density education.field_of_study Social environment Cognition medicine.disease Social relation 030227 psychiatry Causality Hospitalization Psychiatry and Mental health Schizophrenia Cognition Disorders Psychology Social Adjustment Demography |
| Zdroj: | British Journal of Psychiatry. 191:320-324 |
| ISSN: | 1472-1465 0007-1250 |
| DOI: | 10.1192/bjp.bp.106.031328 |
| Popis: | BackgroundPrevious work suggests that the association between urbanicity and schizophrenia may be greatest in those with pre-existing vulnerability.AimsTo test for synergism in risk of schizophrenia between population density and a combined exposure of poor premorbid social and cognitive functioning.MethodFor 371 603 adolescent males examined by the Israeli Draft Board on social and cognitive functioning, data on population density of place of residence and later hospitalisation for schizophrenia were obtained from population-based registries.ResultsThere was an interaction between population density (five levels) and poor premorbid social and cognitive functioning (interaction χ2=4.6,P=0.032). The adjusted increase in cumulative incidence associated with one unit change in population density was 0.10% in the vulnerable group (95% CI 0.019–0.18,P=0.015), nine times larger than that in the non-vulnerable group (0.011%, 95% CI 0.0017–0.020,P=0.021).ConclusionsRisk of schizophrenia may increase when people with a genetic liability to the disorder, expressed as poor social and cognitive functioning, need to cope with city life. |
| Databáze: | OpenAIRE |
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