Cytogenetic and teratological effects of mancozeb pre natal exposure on rats
| Autor: | A. J. Tambasco, L. C. Paraíba, V. L. Castro, D. D. Tambasco |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1999 |
| Předmět: |
Litter (animal)
media_common.quotation_subject lcsh:Biotechnology Population Physiology Fertility Biology Toxicology lcsh:TP248.13-248.65 Prenatal exposure medicine Mancozeb education reproductive and urinary physiology media_common Estrous cycle Pregnancy education.field_of_study Multidisciplinary Genetic evaluation medicine.disease Pre natal Rats Postnatal development Toxicity |
| Zdroj: | Brazilian Archives of Biology and Technology, Volume: 42, Issue: 2, Published: 1999 Brazilian Archives of Biology and Technology, Vol 42, Iss 2, p 0 (1999) ResearcherID Brazilian Archives of Biology and Technology v.42 n.2 1999 Brazilian Archives of Biology and Technology Instituto de Tecnologia do Paraná (Tecpar) instacron:TECPAR |
| Popis: | Studies were conducted on the dam’s fertility and pup viability, litter physical and motor development and chromosomal analysis with female rats exposed to different concentrations of mancozeb, at initial and organogenesis periods of pregnancy. The exposure did not interfere with the pregnant females or their estrous cycle but resulted in retarded physical development, with exception of the vaginal opening and tests descent; which were in advance. The litter body weight was not affected. The examination of swimming performance indicated an initial impairment and a posterior recovery. The observed chromosome damage in dams and pups was found to enhance with the fungicide’s concentration. The results obtained led to the conclusion that even in the absence of maternal signs of toxicity, mancozeb could be related to some genetic damage and teratogenic risk to the population exposed.Foram realizados estudos abordando aspectos relativos a fertilidade, alterações cromossômicas e desenvolvimento da prole de ratas expostas ao fungicida mancozeb em diferentes períodos da prenhez. A exposição não interferiu com a fertilidade ou o ciclo estral das fêmeas, mas ocasionou retardo no desenvolvimento físico dos filhotes, com exceção da descida dos testículos e abertura vaginal que sofreram adiantamento. O peso dos filhotes não foi alterado. O desempenho dos filhotes no teste de natação foi inicialmente prejudicado, mas posteriormente se eqüivaleu ao do grupo controle. Houve ainda alterações cromossômicas, diretamente proporcionais ao aumento da dose empregada. Os resultados indicam que mesmo na ausência de sinais de toxicidade materna, o mancozeb pode estar relacionado a alterações genéticas e risco teratológico nas populações expostas. |
| Databáze: | OpenAIRE |
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