Studies of Transgenic Mosquitoes in Disease-Endemic Countries: Preparation of Containment Facilities
Autor: | Moussa Namountougou, James M. Mutunga, Lakamy Sylla, Mark Q. Benedict, Victor Balyesima, Abdoulaye Diabaté, Lorna Clark, Peter Raymond, Mamadou B. Coulibaly, M. Megan Quinlan, Jonathan K. Kayondo |
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Rok vydání: | 2018 |
Předmět: |
Mosquito Control
Endemic Diseases Operating procedures 030231 tropical medicine Disease compliance Microbiology containment Animals Genetically Modified 03 medical and health sciences Biosafety 0302 clinical medicine Tropical Medicine Virology SITE SELECTION CRITERIA Animals Humans 030212 general & internal medicine Environmental planning Competence (human resources) Public Environmental & Occupational Health mosquitoes transgenic FIELD TRIALS Science & Technology insectary Land use biosafety Original Articles Containment of Biohazards Insect Vectors Malaria Mosquito control Culicidae Infectious Diseases 1117 Public Health And Health Services Africa VECTORS Business Laboratories Life Sciences & Biomedicine Stepwise approach SYSTEM Chain of custody |
Zdroj: | Vector Borne and Zoonotic Diseases |
ISSN: | 1557-7759 1530-3667 |
Popis: | Novel approaches to area-wide control of vector species offer promise as additional tools in the fight against vectored diseases. Evaluation of transgenic insect strains aimed at field population control in disease-endemic countries may involve international partnerships and should be done in a stepwise approach, starting with studies in containment facilities. The preparations of both new-build and renovated facilities are described, including working with local and national regulations regarding land use, construction, and biosafety requirements, as well as international guidance to fill any gaps in regulation. The examples given are for containment categorization at Arthropod Containment Level 2 for initial facility design, classification of wastes, and precautions during shipping. Specific lessons were derived from preparations to evaluate transgenic (non-gene drive) mosquitoes in West and East African countries. Documented procedures and the use of a non-transgenic training strain for trial shipments and culturing were used to develop competence and confidence among the African facility staff, and along the chain of custody for transport. This practical description is offered to support other research consortia or institutions preparing containment facilities and operating procedures in conditions where research on transgenic insects is at an early stage. |
Databáze: | OpenAIRE |
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