Cationic Pd(IV)-Induced Highly Diastereoselective Arylative Cascade Cyclization of Allene-Tethered Cyclohexadienones Leading to Oxygenated Bicyclic Motifs

Autor:	Vankudoth Ramesh, Gullapalli Kumaraswamy, Maram Gangadhar, Balasubramanian Sridhar, Kukkadapu Ankamma
Rok vydání:	2019
Předmět:	Bicyclic molecule 010405 organic chemistry Chemistry Stereochemistry Allene Organic Chemistry Cationic polymerization 010402 general chemistry 01 natural sciences Biochemistry 0104 chemical sciences Catalysis Hydroxylation chemistry.chemical_compound Physical and Theoretical Chemistry Selectfluor
Zdroj:	Organic Letters. 21:6300-6304
ISSN:	1523-7052 1523-7060
DOI:	10.1021/acs.orglett.9b02180
Popis:	A cationic Pd(IV)-catalyzed arylative hydroxylation-Micheal addition of allenyl-tethered cyclohexadienones was developed. This relay reaction could afford highly diastereoselective various functionalized arylative 1,4-dioxane cis-bicyclic structural units with good to high yields. The striking features revealed from these studies is the necessity of Selectfluor and the oxidative hydroxylation originating from water initiated by F–Pd(IV) catalysis. A plausible mechanism was also proposed for this variant observation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3974548a76e9a77dd581a8d669bdd235 https://doi.org/10.1021/acs.orglett.9b02180 Zobrazit plný text záznamu