The circumflex coronary artery occlusion canine model of sudden death: Methodology and electrocardiographic observations
| Autor: | Francis Langlet, Serradimigni A, Jean-Claude Guillen, Paolo Emilio Puddu, Jouve R |
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| Rok vydání: | 1986 |
| Předmět: |
Male
medicine.medical_specialty Resuscitation etiology Coronary Disease Sudden death methods Death Sudden Electrocardiography Dogs Heart Conduction System Heart Rate Coronary Circulation Internal medicine Occlusion Carnivora Animals Medicine ST segment cardiovascular diseases Animals Coronary Circulation Coronary Disease physiopathology Coronary Vessels physiopathology Death Sudden etiology Disease Models Animal Dogs Electrocardiography methods Female Heart Conduction System physiopathology Heart Rate Hemodynamics Male Ventricular Fibrillation physiopathology biology medicine.diagnostic_test Animal business.industry Fissipedia Hemodynamics biology.organism_classification medicine.disease Coronary Vessels Death Disease Models Animal Anesthesia Disease Models Ventricular Fibrillation Ventricular fibrillation Cardiology Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | Journal of Electrocardiology. 19:155-164 |
| ISSN: | 0022-0736 |
| Popis: | This study deals with a left circumflex coronary artery occlusion-reperfusion canine model of sudden death using multiple electrocardiographic leads to define a subgroup of animals at high risk of ventricular fibrillation. Occlusion was followed by ventricular fibrillation in 15 of 30 animals (50%). In the 15 dogs surviving 60 min postocclusion, reperfusion gave rise to ten cases of ventricular fibrillation (66.7%). Thus, the total incidence of occlusion-reperfusion ventricular fibrillation was 25 of 30 (83.3%). Electrocardiographic delta R% changes greater than or equal to 25% in leads 2 and 3 at both 3 and 5 min postocclusion predicted the occurrence of postocclusion ventricular fibrillation with 80% specificity and 56% sensitivity. However, ST segment elevation greater than or equal to 0.5 mV in the same leads at the same times predicted postocclusion ventricular fibrillation with 67% specificity and 100% sensitivity. When only dogs with ST segment elevation greater than or equal to 0.5 mV in leads 2 and 3 at both 3 and 5 min postocclusion were considered, ventricular fibrillation postocclusion was seen in 15 of 20 dogs (75%) and ventricular fibrillation after reperfusion occurred in four of the remaining five animals (80%). Thus, in the subgroup of animals presenting with ST segment elevation greater than or equal to 0.5 mV in leads 2 and 3 at both 3 and 5 min postocclusion, the overall incidence of occlusion-reperfusion ventricular fibrillation was 19 of 20 (95%). These data may be useful in studies aimed at testing the effectiveness of drugs or other interventions in a canine model of sudden death. |
| Databáze: | OpenAIRE |
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