Estimation of Renal Tubular Secretion in Man, in Health and Disease, Using Endogenous N-1-Methylnicotinamide
| Autor: | S. Waldek, F. W. Ballardie, P.T. Daley-Yates, A. Maïza |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Adult
Male Niacinamide medicine.medical_specialty Renal function Endogeny Creatine chemistry.chemical_compound Renal tubular secretion Internal medicine medicine Humans Aged Aged 80 and over Kidney Creatinine Nicotinamide business.industry Middle Aged Renal tubular function Kidney Tubules Endocrinology medicine.anatomical_structure chemistry Female Kidney Diseases business Biomarkers Glomerular Filtration Rate |
| Zdroj: | Nephron. 60:12-16 |
| ISSN: | 2235-3186 1660-8151 |
| Popis: | We have been investigating the possibility of using the renal clearance of endogenous N-1-methylnicotinamide (NMN) as a marker of renal tubular function. Sixty-three subjects (11 healthy volunteers and 52 patients with renal impairment) were used for this study. The subjects were divided into three groups according to their creatinine clearance: group 1, over 80 ml/min; group 2, between 30 and 80 ml/min, and group 3, less than 30 ml/min. The correlation between NMN and creatinine clearance was compared for each group. A good correlation (r = 0.84) was found for groups 1 and 3 (r = 0.76), whereas for group 2, a poor correlation was found (r = 0.43). For subjects with mild renal impairment (group 2), there was clear evidence of glomerulo-tubular imbalance manifest by a larger variability in NMN clearance than creatinine clearance and an essentially non-parallel decline in these two parameters for this group. When all subjects were grouped together, the relationship between the clearance of NMN and of creatinine was best described by a 3-term polynomial equation (r = 0.93). NMN clearance is a potentially useful non-invasive marker of renal tubular function in man and provides additional information to that provided by the measurement of creatinine clearance alone. This substance should be more fully evaluated as a potential diagnostic aid. |
| Databáze: | OpenAIRE |
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