The long term effect of metabolic profile and microbiota status in early gastric cancer patients after subtotal gastrectomy

Autor: Po-Hsiang Ting, Jiing-Chyuan Luo, Fa-Yauh Lee, Ming-Chih Hou, Kuo Hung Huang, Wen-Liang Fang, Xi-Hsuan Lin, Chung-Chi Lin, Shih-Hao Young, Wei-Hung Chuang
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
Male
medicine.medical_treatment
Cancer Treatment
lcsh:Medicine
Gut flora
Gastroenterology
Endocrinology
Medicine and Health Sciences
lcsh:Science
Billroth II
Multidisciplinary
biology
Genomics
Middle Aged
Roux-en-Y anastomosis
Surgical Oncology
Oncology
Medical Microbiology
Metabolome
Female
Research Article
Clinical Oncology
medicine.medical_specialty
Endocrine Disorders
Surgical and Invasive Medical Procedures
Microbial Genomics
Anastomosis
Microbiology
03 medical and health sciences
Digestive System Procedures
Gastrectomy
Stomach Neoplasms
Internal medicine
Diabetes mellitus
Gastrointestinal Tumors
medicine
Genetics
Diabetes Mellitus
Humans
Aged
Neoplasm Staging
Bacteria
business.industry
lcsh:R
Gut Bacteria
Organisms
Cancers and Neoplasms
Biology and Life Sciences
Anastomosis
Roux-en-Y
medicine.disease
biology.organism_classification
Early Gastric Cancer
Gastrointestinal Microbiome
Gastric Cancer
030104 developmental biology
Metabolic Disorders
lcsh:Q
Microbiome
Metabolic syndrome
Clinical Medicine
business
Zdroj: PLoS ONE
PLoS ONE, Vol 13, Iss 11, p e0206930 (2018)
ISSN: 1932-6203
Popis: Long term effects of subtotal gastrectomy on gut microbiota modifications with subsequent metabolic profiles are limited. We aimed to investigate and compare long-term effects of metabolic profiles and microbiota status in early gastric cancer patients post curative subtotal gastrectomy to the controls. In this cross-sectional study, we analyzed type II diabetes mellitus and metabolic syndrome occurrence in two groups: 111 patients after curative subtotal gastrectomy with Billroth II (BII) anastomosis and Roux-en-Y gastrojejuno (RYGJ) anastomosis and 344 age-sex matched controls. Fecal samples from those with BII, RYGJ, and controls were analyzed by next-generation sequencing method. Metabolic syndrome and type II diabetes mellitus occurrences were significantly lower in patients after subtotal gastrectomy with RYGJ than in controls over the long term (> 8 years) follow-up (P < 0.05). The richness and diversity of gut microbiota significantly increased after subtotal gastrectomy with RYGJ (P < 0.05). Compared with the control group, the principal component analysis revealed significant differences in bacterial genera abundance after subtotal gastrectomy with BII and RYGJ (P < 0.001). Genera of Oscillospira, Prevotella, Coprococcus, Veillonella, Clostridium, Desulfovibrio, Anaerosinus, Slackia, Oxalobacter, Victivallis, Butyrivibrio, Sporobacter, and Campylobacter shared more abundant roles both in the RYGJ group and BII groups. Early gastric cancer patients after subtotal gastrectomy with RYGJ had a lower occurrence of metabolic syndrome and type II diabetes mellitus than the controls during long term follow-up. In parallel with the metabolic improvements, gut microbial richness and diversity also significantly increased after subtotal gastrectomy with RYGJ.
Databáze: OpenAIRE
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