Recovery evaluation of rats' damaged tibias: Implantation of core-shell structured bone scaffolds made using hollow braids and a freeze-thawing process
| Autor: | Jia-Horng Lin, Shih-Peng Wen, Yueh-Sheng Chen, Chien-Lin Huang, Chih-Kuang Chen, Shu-Ting Kuo, Ching-Wen Lou, Mong-Chuan Lee |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
food.ingredient
Materials science Scanning electron microscope Bioengineering 02 engineering and technology 010402 general chemistry 01 natural sciences Polyvinyl alcohol Gelatin Bone and Bones Biomaterials chemistry.chemical_compound food Tissue engineering Freezing medicine Braid Animals Tibia Composite material Tissue Engineering Tissue Scaffolds Ossification 021001 nanoscience & nanotechnology 0104 chemical sciences Rats Compressive strength Durapatite chemistry Mechanics of Materials medicine.symptom 0210 nano-technology Porosity |
| Zdroj: | Materials scienceengineering. C, Materials for biological applications. 79 |
| ISSN: | 1873-0191 |
| Popis: | This study prepares biodegradable bone scaffolds helping the recovery of damaged tibias of rats. Polyvinyl alcohol (PVA) plied yarns are fabricated into hollow braids. The braids are combined with hydroxyapatite (HA)/gelatin/PVA mixtures and processed using freeze-thawing and freeze-drying processes in order to form bone scaffolds. These bone scaffolds are observed by scanning electron scope (SEM) and tested for compression strength. Afterwards, recovery of damaged bone, the morphology of the bone, and the histological observation are evaluated. Results indicate a small amount of HA helps in enhancing the compressive strength of bone scaffolds. Results of in vivo assay indicate the damaged tibias of rats recover and function well eight weeks after the implantation, and exhibit a normal morphology. Histological observation confirms the bone scaffolds gradually decompose, allowing tissue infiltration and facilitating ossification. This study successfully produces bone scaffolds with satisfactory mechanical properties helping in the recovery of damaged tibias of rats. |
| Databáze: | OpenAIRE |
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