Recruiting volunteers for a multisite phase I/II HIV preventive vaccine trial in Thailand
| Autor: | Supa Naksrisook, Arthur Brown, Punnee Pitisuttithum, Prasong Srisaengchai, Prasert Thongchareon, Nampueng Sirijongdee, Joseph Chiu, Catherine Chaddic, Patricia Morgan, Valai Bussaratid, Pornchai Sornsathapornkul, Wantanee Boenim, Siriluck Wongkamhaeng, Auchara Sontirat, Richard A. Jenkins, Chirasak Khamboonruang, Benjaluck Phonrat, Chanmet Suwanarach, Sorachai Nitayaphan, Darawan Thapinta |
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| Rok vydání: | 2002 |
| Předmět: |
Adult
Male Human immunodeficiency virus (HIV) HIV Infections medicine.disease_cause Clinical Trials Phase II as Topic Acquired immunodeficiency syndrome (AIDS) Double-Blind Method Medicine Humans Multicenter Studies as Topic Pharmacology (medical) AIDS Vaccines biology Clinical Trials Phase I as Topic business.industry Patient Selection Vaccine trial Middle Aged biology.organism_classification medicine.disease Thailand Clinical trial Vaccination Infectious Diseases Clinical research Phase i ii Lentivirus Immunology HIV-1 Female business Demography |
| Zdroj: | Journal of acquired immune deficiency syndromes (1999). 30(5) |
| ISSN: | 1525-4135 |
| Popis: | Factors believed to be predictive of retention through the recruitment and screening processes for preventive HIV trials were investigated in a large multisite phase I/II HIV vaccine trial in Thailand. Retention through recruitment was equal to or greater than in previous smaller trials with similar populations. The data suggested that recruitment proceeded in a stepwise manner with different influences at each step. Demographic and motivational variables were most important in predicting retention in making and keeping screening appointments. Altruistic or mixed altruistic and nonaltruistic motives were associated with greater retention. Laboratory/medical variables appeared to be the main influence on retention during screening, although some volunteers withdrew for different reasons. The frequent presence of mixed (altruistic and nonaltruistic) motives at initial contact suggests that motivation for trials is more complex than has been previously acknowledged. |
| Databáze: | OpenAIRE |
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