An experimental contribution to the study of the pathogenesis of bovine viral diarrhea virus infection
| Autor: | G Castrucci, M. Ferrari, Bennie Osburn, V. Traldi |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
animal diseases
viruses Immunology Disease Vaccines Attenuated complex mixtures Microbiology Virus Pathogenesis Leukocyte Count Cytopathogenic Effect Viral Neutralization Tests medicine Immunology and Allergy Animals Viral diarrhea Dexamethasone Immunosuppression Therapy Diarrhea Viruses Bovine Viral General Veterinary biology Pestivirus Vaccination virus diseases General Medicine biochemical phenomena metabolism and nutrition biology.organism_classification Virology Infectious Diseases Togaviridae Bovine Virus Diarrhea-Mucosal Disease Cattle Viral disease medicine.drug |
| Zdroj: | Comparative immunology, microbiology and infectious diseases. 15(3) |
| ISSN: | 0147-9571 |
| Popis: | This presentation summarizes the results of a study on the pathogenesis of bovine viral diarrhea (BVDV) infection. The cytopathic (CP) strain TVM-2 of BVDV induced in calves an overt clinical disease which is usually recorded as the acute primary BVDV infection observed under natural conditions. In contrast the non-cytopathic (NCP) strain New York-1 of BVDV did not cause any significant signs of disease. However, when the calves were immunosuppressed by treatment with dexamethasone (DMS) the biotype of BVDV involved did not seem to be as important as it appeared to be in an immunologically normal animal. This was shown in this study by the NCP BVDV which caused a fatal disease in calves treated with DMS. A mixed infection given to calves by injecting them with both CP and NCP BVDV, did not result in any particularly serious disease. So, the potential immunosuppressive activity of BVDV itself for the host has not been proven under the experimental procedures used in this experiment. Finally, a modified-live CP BVDV vaccine was unable to cause clinical disease when injected into calves that had been infected previously with strain New York-1 of BVDV. |
| Databáze: | OpenAIRE |
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