Function, Regulation, and Pathophysiological Relevance of the POT Superfamily, Specifically PepT1 in Inflammatory Bowel Disease
| Autor: | Emilie Viennois, Didier Merlin, Adani Pujada, Jane Zen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Oligopeptide Symporters Chemistry Membrane Transport Proteins Transporter Biological Transport Tripeptide Inflammatory Bowel Diseases Peptide Transporter 1 Transmembrane protein Article Cell biology 03 medical and health sciences 030104 developmental biology Animals Humans Amino Acid Sequence Integral membrane protein Peptide sequence Sequence Alignment Homeostasis Function (biology) |
| Zdroj: | Comprehensive Physiology |
| Popis: | Mammalian members of the proton-coupled oligopeptide transporter family are integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs and couple substrate translocation to the movement of H+ , with the transmembrane electrochemical proton gradient providing the driving force. Peptide transporters are responsible for the (re)absorption of dietary and/or bacterial di- and tripeptides in the intestine and kidney and maintaining homeostasis of neuropeptides in the brain. These proteins additionally contribute to absorption of a number of pharmacologically important compounds. In this overview article, we have provided updated information on the structure, function, expression, localization, and activities of PepT1 (SLC15A1), PepT2 (SLC15A2), PhT1 (SLC15A4), and PhT2 (SLC15A3). Peptide transporters, in particular, PepT1 are discussed as drug-delivery systems in addition to their implications in health and disease. Particular emphasis has been placed on the involvement of PepT1 in the physiopathology of the gastrointestinal tract, specifically, its role in inflammatory bowel diseases. © 2018 American Physiological Society. Compr Physiol 8:731-760, 2018. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|