Inflammatory markers are associated with quality of life, physical activity, and gait speed but not sarcopenia in aged men (40–79 years)
| Autor: | Ilpo Huhtaniemi, Frederick C. W. Wu, Lenore Dedeyne, Gyorgy Bartfai, Aleksander Giwercman, Jos Tournoy, Evelien Gielen, Terence W O'Neill, Giulia Rastrelli, Leen Antonio, Margus Punab, Felipe F. Casanueva, Jolanta Słowikowska-Hilczer, Mario Maggi, Jolan Dupont, Katrien Koppo, Dirk Vanderschueren |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Sarcopenia Population Isometric exercise Diseases of the musculoskeletal system Body Mass Index Quality of life Physiology (medical) Internal medicine medicine Humans Orthopedics and Sports Medicine Older adult education Exercise Aged Geriatrics Inflammation education.field_of_study Hand Strength business.industry Muscle strength QM1-695 Original Articles Middle Aged medicine.disease Inflammaging Walking Speed Ageing Cross-Sectional Studies RC925-935 Cohort Human anatomy Lean body mass Quality of Life Original Article business Body mass index human activities |
| Zdroj: | Journal of Cachexia, Sarcopenia and Muscle Journal of Cachexia, Sarcopenia and Muscle, Vol 12, Iss 6, Pp 1818-1831 (2021) Dupont, J, Antonio, L, Dedeyne, L, O'Neill, T W, Vanderschueren, D, Rastrelli, G, Maggi, M, Bártfai, G, Casanueva, F F, Giwercman, A, Słowikowska-Hilczer, J, Punab, M, Huhtaniemi, I T, Wu, F C W, Tournoy, J, Koppo, K & Gielen, E 2021, ' Inflammatory markers are associated with quality of life, physical activity, and gait speed but not sarcopenia in aged men (40-79 years) ', Journal of cachexia, sarcopenia and muscle . https://doi.org/10.1002/jcsm.12785 |
| ISSN: | 2190-6009 2190-5991 2003-2005 |
| DOI: | 10.1002/jcsm.12785 |
| Popis: | BACKGROUND: Age-related chronic low-grade inflammation (inflammaging) is one of the proposed mechanisms behind sarcopenia. However, findings regarding inflammatory markers in sarcopenic older adults are conflicting. This study aimed to determine the association between inflammatory markers, prevalent as well as incident sarcopenia, sarcopenia-defining parameters, quality of life (QoL), and physical activity in middle-aged and older men. METHODS: Men aged 40-79 years (mean 59.66 ± 11.00y) were recruited from population registers in eight European centres for participation in the European Male Aging study (EMAS). Subjects were assessed at baseline (2003-2005) and again after a median follow-up of 4.29 years. In 2577 participants, associations between baseline inflammatory markers [high-sensitive C-reactive protein (hs-CRP), white blood cell count (WBC), albumin] and baseline physical activity (PASE) and QoL (SF-36) were analysed. In the Leuven and Manchester cohort (n = 447), data were available on muscle mass (whole-body dual X-ray absorptiometry) and strength. In this subgroup, cross-sectional associations between baseline inflammatory markers and sarcopenia-defining parameters (handgrip strength, chair stand test, appendicular lean mass, and gait speed) and prevalent sarcopenia were examined. In a further subgroup (n = 277), associations with knee extensor strength were explored. Longitudinally, predictive value of baseline inflammation on functional decline, physical activity, QoL, and incident sarcopenia was examined. Subgroup analyses were performed in subgroups with chronic inflammation and stratified by age. Linear and logistic regressions were used, adjusted for age, body mass index, centre, and smoking. RESULTS: At baseline, hs-CRP and WBC were negatively associated with PASE score (hs-CRP: β = -7.920, P |
| Databáze: | OpenAIRE |
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