Corrigendum to: Inhibition of Matrix Metalloproteinase 9 Activity Promotes Synaptogenesis in the Hippocampus
| Autor: | Bartosz Caban, Klaudia Nowicka, Diana Legutko, Anna Beroun, Tomasz Kowalczyk, Bogna Badyra, Paulina Kaźmierska-Grębowska, Leszek Kaczmarek, Ahmad Salamian |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Patch-Clamp Techniques
Cognitive Neuroscience Neurogenesis Synaptogenesis Hippocampus Cholinergic Agonists Matrix Metalloproteinase Inhibitors Cellular and Molecular Neuroscience Text mining Animals AcademicSubjects/MED00385 CA1 Region Hippocampal Neuronal Plasticity business.industry Chemistry AcademicSubjects/SCI01870 Excitatory Postsynaptic Potentials Matrix metalloproteinase 9 Rats Matrix Metalloproteinase 9 AcademicSubjects/MED00310 Carbachol business Corrigendum Neuroscience |
| Zdroj: | Cerebral Cortex (New York, NY) |
| ISSN: | 1460-2199 1047-3211 |
| Popis: | Information coding in the hippocampus relies on the interplay between various neuronal ensembles. We discovered that the application of a cholinergic agonist, carbachol (Cch), which triggers oscillatory activity in the gamma range, induces the activity of matrix metalloproteinase 9 (MMP-9)-an enzyme necessary for the maintenance of synaptic plasticity. Using electrophysiological recordings in hippocampal organotypic slices, we show that Cch potentiates the frequency of miniature inhibitory and excitatory postsynaptic currents (mIPSCs and mEPSCs, respectively) in CA1 neurons and this effect is MMP-9 dependent. Interestingly, though MMP-9 inhibition prevents the potentiation of inhibitory events, it further boosts the frequency of excitatory mEPSCs. Such enhancement of the frequency of excitatory events is a result of increased synaptogenesis onto CA1 neurons. Thus, the function of MMP-9 in cholinergically induced plasticity in the hippocampus is to maintain the fine-tuned balance between the excitatory and the inhibitory synaptic transmission. |
| Databáze: | OpenAIRE |
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