Chronic urticaria and thyroid pathology
| Autor: | Mario Sánchez-Borges, Sandra Nora González-Díaz, José Ignacio Canseco-Villarreal, Rosa Ivett Guzman-Avilan, Alfredo Arias-Cruz, Diana Maria Rangel-Gonzalez |
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| Rok vydání: | 2018 |
| Předmět: |
Urticaria
Graves' disease medicine.medical_treatment Levothyroxine AD autoimmune diseases Autoimmunity Immunoglobulin E 0302 clinical medicine immune system diseases TG thyroglobulin AAbs autoantibodies Immunology and Allergy IL Interleukin TNF-α tumor necrosis factor alpha 030223 otorhinolaryngology skin and connective tissue diseases biology TGAbs anti-thyroglobulin antibodies AMA antithyroid microsomal antibody IgG Immunoglobulin G GD Graves' disease Thyroid disease CU chronic urticaria Chronic urticaria BAT basophil activation test VEGF vascular endothelial growth factor Anti-thyroid autoantibodies TSH thyroid stimulating hormone medicine.symptom ASST autologous serum skin test medicine.drug Histamine Pulmonary and Respiratory Medicine lcsh:Immunologic diseases. Allergy medicine.medical_specialty Immunology FcεRIa high affinity IgE receptor TSHR thyroid stimulating hormone receptor Article TLR Toll-like receptors 03 medical and health sciences ICU inducible chronic urticaria PAMPs pathogen-associated molecular patterns T4L free thyroxine medicine IFN-γ gamma interferon NSAH non-sedating antihistamines PAF platelet activating factor Angioedema business.industry Autoantibody AE angioedema HT Hashimoto's thyroiditis/autoimmune thyroiditis CSU chronic spontaneous urticaria medicine.disease Dermatology TPOAbs anti-thyroid peroxidase antibodies ATD autoimmune thyroid disease Treg regulatory T cells IgE Immunoglobulin E UAS urticaria activity score 030228 respiratory system CAU chronic autoimmune urticaria DAMPs damage-associated molecular patterns biology.protein Thyroglobulin business lcsh:RC581-607 ATAbs anti-thyroid autoantibodies |
| Zdroj: | The World Allergy Organization Journal World Allergy Organization Journal, Vol 13, Iss 3, Pp-(2020) |
| ISSN: | 1939-4551 |
| Popis: | Urticaria is defined as the sudden appearance of erythematous, itchy wheals of variable size, with or without angioedema (AE) (swelling of the deeper layers of the skin). Its classification depends on time course of symptoms and the presence of eliciting factors. When it lasts less than 6 weeks it is classified as acute urticaria (AU), and if the symptoms persist for more than 6 weeks, it is classified as chronic urticaria (CU). Current International Guidelines also classify CU as chronic spontaneous urticaria (CSU) and inducible urticarial, according to the absence or presence of environmental triggering factors. CSU is defined as urticaria and/or angioedema in which there is no evidence of a specific eliciting factor. CSU is associated with autoimmunity in 30–45% of the cases, sharing some immunological mechanisms with other autoimmune diseases, and is associated with autoimmune thyroid disease (ATD) in about 4.3%–57.4% patients. Several studies suggest that adequate therapy with anti-thyroid drugs or levothyroxine in early stages of ATD and CSU, may help to remit the latter; but there is still a lack of double-blind, placebo-controlled studies that support this hypothesis in patients without abnormal thyroid hormone levels. The objective of this review is to describe the pathophysiology of chronic spontaneous urticaria and its association with autoimmune thyroid disease. Keywords: Autoimmunity, Chronic urticaria, Histamine, Levothyroxine, Urticaria, Thyroid disease |
| Databáze: | OpenAIRE |
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