ProbioticLactobacillusdose required to restore and maintain a normal vaginal flora

Autor: Andrew W. Bruce, Christine Heinemann, Gregor Reid, Dee Beuerman
Rok vydání: 2001
Předmět:
Zdroj: FEMS Immunology & Medical Microbiology. 32:37-41
ISSN: 1574-695X
0928-8244
DOI: 10.1111/j.1574-695x.2001.tb00531.x
Popis: Forty-two healthy women were randomized to receive one of three encapsulated Lactobacillus rhamnosus GR-1 plus Lactobacillus fermentum RC-14 probiotic dosage regimens or L. rhamnosus GG by mouth each day for 28 days. However, the vaginal flora, assessed by Nugent scoring, was only normal in 40% of the cases, and 14 patients had asymptomatic bacterial vaginosis. Treatment with L. rhamnosus GR-1/L. fermentum RC-14 once and twice daily correlated with a healthy vaginal flora in up to 90% of patients, and 7/11 patients with bacterial vaginosis converted to normal or intermediate scores within 1 month. Ingestion of L. rhamnosus GG failed to have an effect. This study confirms the potential efficacy of orally administered lactobacilli as a non-chemotherapeutic means to restore and maintain a normal urogenital flora, and shows that over 10 8 viable organisms per day is the required dose. fl 2001 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.
Databáze: OpenAIRE