Specific Activation of Dendritic Cells Enhances Clearance of Bacillus anthracis following Infection

Autor: Stella C. Knight, Nicholas R. English, Diane Williamson, Elizabeth R. Mann, Iain J. T. Thompson, Margaret G. M. Stokes
Rok vydání: 2014
Předmět:
Adoptive cell transfer
T-Lymphocytes
lcsh:Medicine
VACCINE
Mice
Bone Marrow
Cytotoxic T cell
PROTECTION
lcsh:Science
Immunity
Cellular
Multidisciplinary
biology
Vaccination
Infectious Disease Immunology
Vaccination and Immunization
IMMUNIZATION
Adoptive Transfer
Bacillus anthracis
Multidisciplinary Sciences
MOUSE BONE-MARROW
Science & Technology - Other Topics
Cytokines
Cell Division
Research Article
STRAIN
General Science & Technology
Immunology
chemical and pharmacologic phenomena
IMMUNITY
Microbiology
Anthrax
Immune system
Antigen
Splenocyte
Animals
Humans
Antigens
Bacterial
Science & Technology
CD40
Antibacterial Therapy
lcsh:R
Biology and Life Sciences
Dendritic Cells
biology.organism_classification
Survival Analysis
Immune System
biology.protein
lcsh:Q
Clinical Immunology
Spleen
Ex vivo
Zdroj: PLoS ONE
PLoS ONE, Vol 9, Iss 11, p e109720 (2014)
ISSN: 1932-6203
Popis: Dendritic cells are potent activators of the immune system and have a key role in linking innate and adaptive immune responses. In the current study we have used ex vivo pulsed bone marrow dendritic cells (BMDC) in a novel adoptive transfer strategy to protect against challenge with Bacillus anthracis, in a murine model. Pre-pulsing murine BMDC with either recombinant Protective Antigen (PA) or CpG significantly upregulated expression of the activation markers CD40, CD80, CD86 and MHC-II. Passive transfusion of mice with pulsed BMDC, concurrently with active immunisation with rPA in alum, significantly enhanced (p
Databáze: OpenAIRE
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