Genetic associations with human longevity at the APOE and ACE loci
| Autor: | François Schächter, Philippe Froguel, Laurence Faure-Delanef, Laurence Lesueur-Ginot, Hervé Rouger, Daniel Cohen, Frédérique Guénot |
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| Rok vydání: | 1994 |
| Předmět: |
Adult
Male Apolipoprotein E Candidate gene Genotype media_common.quotation_subject Longevity Molecular Sequence Data Peptidyl-Dipeptidase A Biology Apolipoproteins E Gene Frequency Polymorphism (computer science) Genetics Humans Allele Allele frequency Alleles Aged media_common Aged 80 and over Sex Characteristics Polymorphism Genetic Base Sequence Case-control study Middle Aged Case-Control Studies Female France |
| Zdroj: | Nature Genetics. 6:29-32 |
| ISSN: | 1546-1718 1061-4036 |
| DOI: | 10.1038/ng0194-29 |
| Popis: | In an effort to dissect the genetic components of longevity, we have undertaken case-control studies of populations of centenarians (n = 338) and adults aged 20-70 years at several polymorphic candidate gene loci. Here we report results on two genes, chosen for their impact on cardiovascular risk, encoding apolipoprotein E (ApoE), angiotensin-converting enzyme (ACE). We find that the epsilon 4 allele of APOE, which promotes premature atherosclerosis, is significantly less frequent in centenarians than in controls (p < 0.001), while the frequency of the epsilon 2 allele, associated previously with type III and IV hyperlipidemia, is significantly increased (p < 0.01). A variant of ACE which predisposes to coronary heart disease is surprisingly more frequent in centenarians, with a significant increase of the homozygous genotype (p < 0.01). These associations provide examples of genetic influences on differential survival and may point to pleiotropic age-dependent effects on longevity. |
| Databáze: | OpenAIRE |
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