Association of DC-SIGN promoter polymorphism with increased risk for parenteral, but not mucosal, acquisition of human immunodeficiency virus type 1 infection
| Autor: | Susan Buchbinder, Holli B. Hutcheson, Stephen J. O'Brien, James J. Goedert, Maureen P. Martin, Roger Detels, George W. Nelson, Yvette van Kooyk, David Vlahov, Michael M. Lederman, Mary Carrington, Keith Hoots |
|---|---|
| Přispěvatelé: | Molecular cell biology and Immunology |
| Jazyk: | angličtina |
| Rok vydání: | 2004 |
| Předmět: |
Immunology
HIV Infections Receptors Cell Surface Microbiology Virus Cohort Studies Acquired immunodeficiency syndrome (AIDS) Virology Immunopathology medicine Humans Infusions Parenteral Lectins C-Type Sida Promoter Regions Genetic Mucous Membrane Polymorphism Genetic biology Odds ratio biology.organism_classification medicine.disease DC-SIGN Insect Science Lentivirus biology.protein HIV-1 Pathogenesis and Immunity Viral disease Cell Adhesion Molecules |
| Zdroj: | Martin, M P, Lederman, M M, Hutcheson, H B, Goedert, J J, Nelson, G W, van Kooyk, Y, Detels, R, Buchbinder, S, Hoots, K, Vlahov, D, O'Brien, S J & Carrington, M 2004, ' Association of DC-SIGN promoter polymorphism with increased risk for parenteral, but not mucosal, acquisition of human immunodeficiency virus type 1 infection ', Journal of Virology, vol. 78, no. 24, pp. 14053-6 . https://doi.org/10.1128/JVI.78.24.14053-14056.2004 Journal of Virology, 78(24), 14053-6. American Society for Microbiology |
| ISSN: | 0022-538X |
| Popis: | There is considerable debate about the fundamental mechanisms that underlie and restrict acquisition of human immunodeficiency virus type 1 (HIV-1) infection. In light of recent studies demonstrating the ability of C type lectins to facilitate infection with HIV-1, we explored the potential relationship between polymorphisms in the DC-SIGN promoter and risk for acquisition of HIV-1 according to route of infection. Using samples obtained from 1,611 European-American participants at risk for parenteral ( n = 713) or mucosal ( n = 898) infection, we identified single-nucleotide polymorphisms in the DC-SIGN promoter using single-strand conformation polymorphism. Individuals at risk for parenterally acquired infection who had −336C were more susceptible to infection than were persons with −336T (odds ratio = 1.87, P = 0.001). This association was not observed in those at risk for mucosally acquired infection. A potential role for DC-SIGN specific to systemic acquisition and dissemination of infection is suggested. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|