Metabolic disturbances of non-alcoholic fatty liver resemble the alterations typical for type 2 diabetes

Autor: Bram Brouwers, Matthijs K. C. Hesselink, Michael Roden, Dennis Dahlmans, Patrick Schrauwen, Tomas Jelenik, Anne Gemmink, Bas Havekes, Yvonne M. H. Bruls, Vera B. Schrauwen-Hinderling
Přispěvatelé: Promovendi NTM, RS: NUTRIM - R1 - Obesity, diabetes and cardiovascular health, RS: NUTRIM - HB/BW section B, MUMC+: DA BV Klinisch Fysicus (9), RS: NUTRIM - R1 - Metabolic Syndrome, Interne Geneeskunde, MUMC+: MA Endocrinologie (9), Beeldvorming
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Adult
Male
medicine.medical_specialty
Magnetic Resonance Spectroscopy
endocrine system diseases
GLUCOSE-PRODUCTION
Glucose uptake
030209 endocrinology & metabolism
Type 2 diabetes
Biology
DISEASE
03 medical and health sciences
0302 clinical medicine
Insulin resistance
Non-alcoholic Fatty Liver Disease
Internal medicine
medicine
Humans
Insulin
Aerobic exercise
In patient
Risk factor
HEPATIC STEATOSIS
Muscle
Skeletal
Aged
Fatty liver
nutritional and metabolic diseases
Non alcoholic
General Medicine
NATURAL-HISTORY
Middle Aged
MAGNETIC-RESONANCE-SPECTROSCOPY
Lipid Metabolism
medicine.disease
PREVALENCE
Endocrinology
TISSUE INSULIN-RESISTANCE
Adipose Tissue
Diabetes Mellitus
Type 2
Liver
INTRAHEPATIC TRIGLYCERIDE CONTENT
Body Composition
Glucose Clamp Technique
SKELETAL-MUSCLE
030211 gastroenterology & hepatology
Insulin Resistance
SENSITIVITY
Zdroj: Clinical Science, 131(15), 1905-1917. Portland Press Ltd.
ISSN: 0143-5221
DOI: 10.1042/cs20170261
Popis: Non-alcoholic fatty liver (NAFL) is an independent risk factor for the development of type 2 diabetes (T2DM). We examined metabolic perturbations in patients with NAFL, patients with T2DM, and control (CON) subjects with normal intrahepatic lipid (IHL) content. A two-step (10 mU/m2 /min; 40 mU/m2/min) hyperinsulinemic–euglycemic clamp was performed in 11 NAFL, 13 T2DM, and 11 CON subjects, all matched for BMI, and aerobic fitness. IHL content was measured using proton magnetic resonance spectroscopy. Because of high IHL content variability in T2DM patients, this group was separated into a high IHL content group (IHL ≥ 5.0%, T2DM+NAFL) and a normal IHL content group (IHL < 5.0%, T2DM-non-NAFL) for further analysis. IHL content was increased in NAFL and T2DM+NAFL subjects (P0.05), and was lower in comparison with CON subjects (all P Individuals with NAFL suffer from metabolic perturbations to a similar degree as T2DM patients. NAFL is an important feature leading to severe insulin resistance and should be viewed as a serious health threat for the development of T2DM. ClinicalTrials.gov: NCT01317576
Databáze: OpenAIRE
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