| Autor: |
Yi-Kan Wu, Chia-Hau Chang, Jiun-Hao Yu, Kai-Ping Lan, Tzung-Hai Yen, Shu-Sen Chang, Chen-June Seak, Hsing-Yuan Chang, Hsien-Yi Chen |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Clinical toxicology (Philadelphia, Pa.). 60(10) |
| ISSN: |
1556-9519 |
| Popis: |
Avermectin pesticides are widely used in agriculture, and are thought to have low toxicity in humans. However, information on their toxicity after accidental or deliberate ingestion is limited.The aim of this study was to evaluate the clinical manifestations of avermectin pesticide ingestion and identify factors associated with severe outcomes (death, intubation, or sustained hypotension requiring inotrope therapy).This multicenter retrospective study included patients who visited the emergency departments of six teaching hospitals due to acute avermectin pesticide ingestion between January 2012 and May 2020. Patients who reported ingestion of any other pesticides, drugs, or substances were excluded.In total, 64 patients (median age, 72 years) were included: 60 had ingested emamectin pesticides, and 4 had ingested abamectin. Almost all (98%) were cases of self-harm. The most common presentation was drowsiness (47%), with a median Glasgow Coma Scale (GCS) score of 14, followed by shortness of breath (SOB)/dyspnea (33%) and nausea/vomiting (22%). Concurrent methanol exposure (Most patients who intentionally ingested avermectin pesticides required inpatient treatment. Forty-two percent needed ICU care and 31% had severe outcomes. A GCS score13 and SOB/dyspnea were independently associated with severe outcomes. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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