Identification and quantification of ureaplasmas colonizing the respiratory tract and assessment of their role in the development of chronic lung disease in preterm infants

Autor: Janet A. Robertson, David Bar-Shain, Avroy A. Fanaroff, Mary Ann O'Riordan, Bernard Boxerbaum, Alfred D. Heggie
Rok vydání: 2001
Předmět:
Lung Diseases
Male
Microbiology (medical)
Pathology
medicine.medical_specialty
Respiratory System
Colony Count
Microbial
Mycoplasmataceae
urologic and male genital diseases
medicine.disease_cause
fluids and secretions
Risk Factors
Intubation
Intratracheal
medicine
Humans
Infant
Very Low Birth Weight
Prospective Studies
Risk factor
Probability
biology
business.industry
Incidence
Ureaplasma Infections
Respiratory disease
Infant
Newborn
Pulmonary Surfactants
bacterial infections and mycoses
medicine.disease
biology.organism_classification
female genital diseases and pregnancy complications
Logistic Models
Infectious Diseases
Ureaplasma parvum
medicine.anatomical_structure
Inhalation
Bronchopulmonary dysplasia
Chronic Disease
Pediatrics
Perinatology and Child Health
Immunology
Mollicutes
bacteria
Female
business
Ureaplasma urealyticum
Infant
Premature
Respiratory tract
Zdroj: The Pediatric Infectious Disease Journal. 20:854-859
ISSN: 0891-3668
DOI: 10.1097/00006454-200109000-00006
Popis: The role of Ureaplasma urealyticum in the development of chronic lung disease (CLD) in preterm infants continues to be disputed. Recently U. urealyticum has been found to consist of two species, U. urealyticum and Ureaplasma parvum, a finding that has not been considered in previous studies of CLD. This study examined the possible relationships between development of CLD and respiratory colonization by these newly redefined species, their concentrations in lower respiratory secretions and the effect of pulmonary surfactant treatment on these relationships in preterm infants with birth weights1500 g.Endotracheal aspirates (ETA) were collected from intubated infants when airway suctioning was medically required. ETA were stored at -80 degrees C until quantitative cultures for ureaplasmas and Mycoplasma hominis were performed. Culture results were correlated with development of CLD.Of 475 infants (birth weights1500 g) admitted during the 2-year study period, 272 were excluded because they were not intubated or were extubated before ETA could be obtained. An additional 28 infants died, were discharged or were transferred before they could be assessed for CLD. From the remaining 175 infants ureaplasmas were isolated from 66 (38%). No statistically significant associations were identified between development of CLD and the Ureaplasma species isolated, or concentration of ureaplasmas in lower respiratory secretions. These findings were not altered by treatment with pulmonary surfactant (Survanta).Lower respiratory colonization by ureaplasmas does not appear to be a contributory cause of CLD in preterm infants.
Databáze: OpenAIRE
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