The role of superoxide anions in the development of distant tumour recurrence
| Autor: | Leo J. Hofland, Johannes Jeekel, J. B. C. van der Wal, M. T. ten Kate, P Sonneveld, Willem Sluiter, C.H.J. van Eijck |
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| Přispěvatelé: | Radiology & Nuclear Medicine, Biochemistry, Internal Medicine, Surgery, Hematology |
| Rok vydání: | 2006 |
| Předmět: |
Cancer Research
Pathology medicine.medical_specialty Endothelium Apoptosis Biology Adenocarcinoma Superoxide dismutase chemistry.chemical_compound Superoxides Cell Line Tumor medicine Cell Adhesion Humans Neoplasm Metastasis Cell adhesion surgical trauma chemistry.chemical_classification Reactive oxygen species Cell adhesion molecule Superoxide ROS Pancreatic Neoplasms adhesion medicine.anatomical_structure Oncology chemistry Cell culture Colonic Neoplasms Cancer research biology.protein tumour cell Endothelium Vascular microvascular endothelium Translational Therapeutics Cell Adhesion Molecules |
| Zdroj: | British Journal of Cancer British Journal of Cancer, 95, 1497-1503. Nature Publishing Group |
| ISSN: | 0007-0920 |
| Popis: | We hypothesise that reactive oxygen species (ROS) released from activated polymorphonuclear leucocytes during surgery play a crucial role in enhanced tumour recurrence seen after surgery. Therefore, the effect of ROS on adhesion of tumour cells to microvascular endothelium in a reproducible human in vitro model was studied. Preincubation of microvascular endothelial cells with the superoxide anion producing xanthine–xanthine oxidase complex significantly increased adhesion of the human colon carcinoma cells HT29 (167% vs control, P |
| Databáze: | OpenAIRE |
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