Body mass index and glucocorticoid dose contribute to subclinical atherosclerosis in Korean patients with systemic lupus erythematosus: A prospective 4 year follow‐up study
| Autor: | Hyoun-Ah Kim, Hyun-Young Lee, Ju-Yang Jung, Chang-Hee Suh |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Carotid Artery Diseases medicine.medical_specialty Time Factors Carotid arteries Disease Carotid Intima-Media Thickness Body Mass Index Disease activity 03 medical and health sciences 0302 clinical medicine Rheumatology Risk Factors Internal medicine Republic of Korea medicine Humans Lupus Erythematosus Systemic Prospective Studies cardiovascular diseases 030212 general & internal medicine Glucocorticoids 030203 arthritis & rheumatology business.industry Follow up studies Ultrasonography Doppler Odds ratio Middle Aged Plaque Atherosclerotic Subclinical atherosclerosis Asymptomatic Diseases Disease Progression cardiovascular system Female business Body mass index Glucocorticoid Follow-Up Studies medicine.drug |
| Zdroj: | International Journal of Rheumatic Diseases. |
| ISSN: | 1756-185X 1756-1841 |
| Popis: | Aim Patients with systemic lupus erythematosus (SLE) have an increased risk of cardiovascular disease owing to an immunological abnormality, along with traditional risk factors. We found that carotid artery intima-media thickness (cIMT) and plaque were associated with age, body mass index (BMI) and disease activity in a previous study 4 years ago. Our aim was to identify risk factors associated with progression of subclinical atherosclerosis in SLE. Methods We assessed cIMT and plaque using Doppler ultrasonography in 61 Korean women with SLE who were enrolled in the previous study 4 years ago. Results The mean cIMT of the patients was 0.39 ± 0.09 mm; 11 patients had carotid plaques, which was similar to the results of the previous study. Twenty-one patients had increased cIMT, and new carotid plaque had developed in seven patients. Patients with increased cIMT had a lower BMI and took fewer non-steroidal anti-inflammatory drugs and higher 4 year cumulative glucocorticoid dose than patients without increased cIMT. The 4 year cumulative glucocorticoid dose was higher in patients with carotid plaque than in those without. On multivariate regression analysis, BMI (odds ratio [OR] = 0.67, P = 0.034) was associated with increased cIMT, and the 4 year cumulative glucocorticoid dose was associated with increased cIMT (OR = 6.994, P = 0.025) and carotid plaque (OR = 5.651, P = 0.031). Conclusion This prospective follow-up study on cIMT and plaque in patients with SLE showed that low BMI and 4 year cumulative glucocorticoid dose were associated with the progression of subclinical atherosclerosis. |
| Databáze: | OpenAIRE |
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