Low-Grade Papillary Schneiderian Carcinoma: Report of a Case with Molecular Characterization
| Autor: | Giuseppina Ferrario, Fabio Sovardi, Sergio Carnevale, Patrizia Morbini, Marco Benazzo |
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| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Pathology medicine.medical_specialty Nose Neoplasms Inverted papilloma Schneiderian carcinoma Case Report medicine.disease_cause Pathology and Forensic Medicine Metastasis 03 medical and health sciences 0302 clinical medicine Cytology Carcinoma medicine Humans Aged business.industry Sinonasal Tract medicine.disease Carcinoma Papillary Nasal Mucosa 030104 developmental biology Oncology Otorhinolaryngology 030220 oncology & carcinogenesis Immunohistochemistry KRAS business Paranasal Sinus Neoplasms |
| Zdroj: | Head Neck Pathol |
| ISSN: | 1936-0568 |
| DOI: | 10.1007/s12105-019-01067-5 |
| Popis: | In 2015, Lewis et al. first described low-grade papillary Scheneiderian carcinoma (LGPSC) of the sinonasal tract. Their case resembled a sinonasal papilloma clinically and histopathologically; however, invasion and metastasis resulted in the death of the patient despite absence of malignant cytologic features. Additional reports established LGPSC as a distinct entity and characterized its immunohistochemical profile. Diffuse expression of low molecular weight cytokeratins, positivity for p16 and p53 in at least 50% of cells, a high Ki-67 index, and absence of human papillomavirus (HPV)-DNA was observed across all reported cases. We report an additional case of LGPSC and describe the clinical, histologic, and immunohistochemical features. In contrast to sinonasal papillomas, the case was negative for HPV-DNA and showed no mutations in the EGFR and KRAS hotspot regions. |
| Databáze: | OpenAIRE |
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