Relationship between plasma angiogenic growth factors and diabetic foot ulcers
| Autor: | Shasha Fu, Mao-Xiong Fu, Ya-Lian Huang, Zu-Rong Wu, Yi Wang, Zong-Cun Chen, Jin-Yi Chen |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Vascular Endothelial Growth Factor A
0301 basic medicine medicine.medical_specialty Clinical Biochemistry 030209 endocrinology & metabolism Biochemistry Gastroenterology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Risk Factors Diabetes mellitus Internal medicine medicine Humans Prospective cohort study Foot Ulcer Placenta Growth Factor business.industry Biochemistry (medical) General Medicine medicine.disease Diabetic foot Diabetic Foot Vascular endothelial growth factor Vascular endothelial growth factor A 030104 developmental biology Diabetic foot ulcer chemistry Angiogenesis Inducing Agents Wound healing business |
| Zdroj: | Clinica Chimica Acta. 482:95-100 |
| ISSN: | 0009-8981 |
| DOI: | 10.1016/j.cca.2018.03.035 |
| Popis: | Angiogenic growth factors play an important role in wound healing. However, their associations with diabetic foot ulcers (DFUs) in humans have rarely been investigated. We examined the relationships between circulating concentrations of vascular endothelial growth factor (VEGF)-A and placenta growth factor (PlGF), and DFU risk.We recruited 447 participants, including 169 DFU patients, 182 diabetes patients without DFUs, and 96 diabetes-free individuals. Plasma VEGF-A and PlGF concentrations were measured using commercial enzyme immunoassay kits.Concentrations of VEGF-A and PlGF in DFU patients were higher than those in diabetes-free controls (P 0.05), but lower than those in the diabetic controls (P 0.05). Increased concentrations of VEGF-A and PlGF were associated with a reduced risk of DFUs. The odds ratios (95% confidence intervals) were 0.93 (0.88, 0.97) for every 10 pg/ml increase in VEGF-A concentrations, and 0.96 (0.94, 0.99) for every 5 pg/ml increase in PlGF concentrations. VEGF-A concentrations were positively related to BMI, glycated hemoglobin (HbA1c), hypertension, and neuropathy, and PlGF was positively correlated to age, HbA1c, and hypertension, among DFU patients.VEGF-A and PlGF play important roles in the development of DFU but need to be confirmed in prospective studies. |
| Databáze: | OpenAIRE |
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