Mitochondria and Cancer: Past, Present, and Future
| Autor: | Andrew Harbottle, Ryan Parr, Gurmit Singh, Robert G. Ungard, Meghan L. Verschoor, John P. Jakupciak |
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| Rok vydání: | 2013 |
| Předmět: |
Proteomics
Proteomics methods Reactive oxygen species metabolism lcsh:Medicine Genomics Review Article Computational biology Mitochondrion Biology Bioinformatics DNA Mitochondrial Genome General Biochemistry Genetics and Molecular Biology Neoplasms medicine Humans Cell Nucleus Polymorphism Genetic General Immunology and Microbiology lcsh:R Cancer Oxidation reduction Sequence Analysis DNA General Medicine medicine.disease Mitochondria Cell Transformation Neoplastic Genome Mitochondrial Mutation Reactive Oxygen Species Oxidation-Reduction |
| Zdroj: | BioMed Research International, Vol 2013 (2013) BioMed Research International |
| ISSN: | 2314-6141 2314-6133 |
| DOI: | 10.1155/2013/612369 |
| Popis: | The area of mitochondrial genomics has undergone unprecedented growth over the past several years. With the advent of the age of omics, investigations have reached beyond the nucleus to encompass the close biological communication and finely coordinated interactions between mitochondria and their nuclear cell mate. Application of this holistic approach, to all metabolic interactions within the cell, is providing a more complete understanding of the molecular transformation of the cell from normal to malignant behavior, before histopathological indications are evident. In this review the surging momentum in mitochondrial science, as it relates to cancer, is described in three progressive perspectives: (1) Past: the historical contributions to current directions of research; (2) Present: Contemporary findings, results and approaches to mitochondria and cancer, including the role of next generation sequencing and proteomics; (3) Future: Based on the present body of knowledge, the potential assets and benefits of mitochondrial research are projected into the near future. |
| Databáze: | OpenAIRE |
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