Differential contributions of vasopressin V1A and oxytocin receptors in the amygdala to pain-related behaviors in rats
| Autor: | Volker Neugebauer, Guangchen Ji, Bryce Cragg |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Vasopressin Receptors Vasopressin Indoles Pyrrolidines Arginine Microdialysis Relcovaptan Short Report Neuropeptide Pain Carrageenan Rats Sprague-Dawley 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Hormone Antagonists Piperidines Internal medicine Reflex oxytocin Medicine Animals Kaolin Maze Learning Arginine vasopressin receptor 1B Arginine vasopressin receptor 1A business.industry Arthritis amygdala anxiety Oxytocin receptor Benzoxazines Rats Disease Models Animal 030104 developmental biology Anesthesiology and Pain Medicine Endocrinology Oxytocin Receptors Oxytocin Molecular Medicine Vocalization Animal business 030217 neurology & neurosurgery hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Molecular Pain |
| ISSN: | 1744-8069 |
| Popis: | Neuroplastic changes in the amygdala account for emotional-affective aspects of pain and involve neuropeptides such as calcitonin gene-related peptide and corticotropin-releasing factor. Another neuropeptide system, central arginine vasopressin, has been implicated in neuropsychiatric disorders, but its role in pain-related emotional expression and neuroplasticity remains to be determined. Here, we tested the hypothesis that arginine vasopressin in the amygdala contributes to pain-related emotional-affective responses, using stereotaxic applications of arginine vasopressin and antagonists for G-protein coupled vasopressin V1A and oxytocin receptors in adult male Sprague-Dawley rats. In normal animals, arginine vasopressin increased audible and ultrasonic vocalizations and anxiety-like behavior (decreased open-arm preference in the elevated plus maze). The facilitatory effects were blocked by a selective V1A antagonist (SR 49059, Relcovaptan) but not by an oxytocin receptor antagonist (L-371,257). L-371,257 had some facilitatory effects on vocalizations. Arginine vasopressin had no effect in arthritic rats (kaolin/carrageenan knee joint pain model). SR 49059 inhibited vocalizations and anxiety-like behavior (elevated plus maze) in arthritic, but not normal, rats and conveyed anxiolytic properties to arginine vasopressin. Arginine vasopressin, SR 49059, and L-371,257 had no significant effects on spinal reflexes. We interpret the data to suggest that arginine vasopressin through V1A in the amygdala contributes to emotional-affective aspects of pain (arthritis model), whereas oxytocin receptors may mediate some inhibitory effects of the vasopressin system. |
| Databáze: | OpenAIRE |
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